Evidence map›Paper›PMID 33526584›Full record

ArticleGenes & development2021

Learning from the worm: the effectiveness of protein-bound Moco to treat Moco deficiency.

Aileen K Sewell, Min Han

Open access · diamondAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Aileen K SewellDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA.
Min HanDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA.
University of Colorado Boulder · US

Funding

RAS MEDIATED SIGNAL TRANSDUCTION IN C. ELEGANSR01GM047869 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI HAN, MIN · 1992 to 2020
$5.0M
Novel Nutrient Functions and Sensing MechanismsR35GM139631 · NIGMS · UNIVERSITY OF COLORADO · PI MIN HAN · 2021 to 2026
$2.6M
Mechanism by which fatty acid metabolism impacts muscle maintenanceR01AR074503 · NIAMS · UNIVERSITY OF COLORADO · PI HAN, MIN · 2019 to 2023
$1.7M
NIAMS NIH HHS R01 AR074503NIGMS NIH HHS R01 GM047869NIGMS NIH HHS R35 GM139631
6 · The paper itself

Abstract

Molybdenum cofactor (Moco) is synthesized endogenously in humans and is essential for human development. Supplementation of Moco or its precursors has been explored as a therapy to treat Moco-deficient patients but with significant limitations. By using the nematode

Indexed as

Caenorhabditis elegansPteridinesAnimalsCoenzymesHumansMetalloproteinsMetal Metabolism, Inborn ErrorsMolybdenum CofactorsCoenzymesMetalloproteinsMolybdenum CofactorsmolybdopterinPteridinesC. elegansE. colimolybdenum cofactorsulfite oxidase

Identifiers

PMID33526584
PMCPMC7849358
OpenAlexW3128667707

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.