Evidence map›Paper›PMID 33526561›Full record

ArticleInfection and immunity2021

Delineation of the pH-Responsive Regulon Controlled by the Helicobacter pylori ArsRS Two-Component System.

John T Loh, Miranda V Shum, Scott D R Jossart, Anne M Campbell, Neha Sawhney, W Hayes McDonald, Matthew B Scholz, Mark S McClain, Mark H Forsyth, Timothy L Cover

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Methylation Dynamics inMicroorganisms · 2026
    Article
  2. Review
  3. Review
  4. ThemBio · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. mBio · 2024
    Article
  10. Article
  11. Article
  12. Antibiotic-induced ROS-mediated Fur allosterism contributes toAntimicrobial agents and chemotherapy · 2024
    Article
  13. TheJournal of bacteriology · 2024
    Article
  14. Article
  15. A Positively SelectedInfection and immunity · 2023
    Article
  16. Article
  17. Insights into the Orchestration of Gene Transcription Regulators inInternational journal of molecular sciences · 2022
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

John T LohDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Miranda V ShumDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Scott D R JossartDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Anne M CampbellDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Neha SawhneyDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000-0002-4943-1018
W Hayes McDonaldProteomics Laboratory, Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee, USA.
Matthew B ScholzVanderbilt Technologies for Advanced Genetics (VANTAGE), Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Mark S McClainDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000-0002-9857-4883
Mark H ForsythDepartment of Biology, The College of William and Mary, Williamsburg, Virginia, USA.
Timothy L CoverDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA timothy.l.cover@vumc.org.ORCID 0000-0001-8503-002X
Vanderbilt University · USVanderbilt University Medical Center · USWilliam & Mary · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Role of Iron and B-Catenin Activation in Gastric CarcinogenesisP01CA116087 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2009 to 2026
$27.5M
Structure-function analysis of H. pylori VacAR01AI039657 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI TIMOTHY L COVER · 1996 to 2026
$8.3M
Type IV Protein Secretion in Helicobacter pyloriR01AI118932 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COVER, TIMOTHY L, OHI, MELANIE DIANE · 2016 to 2025
$6.7M
Regulatory Mechanisms of Outer Membrane Protein Expression in Helicobacter pyloriR15AI133470 · NIAID · COLLEGE OF WILLIAM AND MARY · PI FORSYTH, MARK H · 2019 to 2019
$413k
"Pathogenesis of Helicobacter pylori Infection"I01BX004447 · VA · VETERANS HEALTH ADMINISTRATION · PI TIMOTHY L COVER · 2019 to 2026
–
BLRD VA I01 BX004447NCI NIH HHS P01 CA116087NCI NIH HHS P30 CA068485NIAID NIH HHS R01 AI039657NIAID NIH HHS R01 AI118932NIAID NIH HHS R15 AI133470NIDDK NIH HHS P30 DK058404
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene Expression Regulation, BacterialHydrogen-Ion ConcentrationResponse ElementsComputational BiologyGene Expression ProfilingHelicobacter pyloriHumansMutationProteomeProteomicsTrans-ActivatorsTranscription, GeneticProteomeTrans-Activatorsgene regulationRNA-seqsignal transductiontwo-component regulatory systemstwo-component signal transduction systems

Identifiers

PMID33526561
PMCPMC8090972
OpenAlexW3128056998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.