ArticleBMJ open2021
Budget impact analysis of routinely using whole-genomic sequencing of six multidrug-resistant bacterial pathogens in Queensland, Australia.
Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- A systematic review of economic evaluations of whole-genome sequencing for the surveillance of bacterial pathogens.Microbial genomics · 2023Pooled it
- Near-real-time whole-genome sequencing in hospital infection control: a narrative review.Infection · 2026Review
- The cost and cost-effectiveness of whole-exome and whole-genome sequencing: a systematic literature review.European journal of human genetics : EJHG · 2026Review
- Genome sequencing for prevention of health-care-associated bacterial infections.Nature reviews. Microbiology · 2026Review
- Methods for cost-efficient, whole genome sequencing surveillance for enhanced detection of outbreaks in a hospital setting.PloS one · 2026Article
- Methods for cost-efficient, whole genome sequencing surveillance for enhanced detection of outbreaks in a hospital setting.medRxiv : the preprint server for health sciences · 2025Article
- Whole-genome sequencing surveillance of vancomycin-resistantInfection control and hospital epidemiology · 2025Article
- Genomics for antimicrobial resistance-progress and future directions.Antimicrobial agents and chemotherapy · 2025Review
- RSYD-BASIC: a bioinformatic pipeline for routine sequence analysis and data processing of bacterial isolates for clinical microbiology.Access microbiology · 2025Article
- The Next Frontier in Tuberculosis Investigation: Automated Whole Genome Sequencing forInternational journal of molecular sciences · 2024Article
- Evaluating the impact of genomic epidemiology of methicillin-resistantMicrobial genomics · 2024Article
- Consideration of within-patient diversity highlights transmission pathways and antimicrobial resistance gene variability in vancomycin-resistant Enterococcus faecium.The Journal of antimicrobial chemotherapy · 2024Article
- Active surveillance of carbapenemase-producing Enterobacterales using genomic sequencing for hospital-based infection control interventions.Infection control and hospital epidemiology · 2024Article
- Economic and health impact modelling of a whole genome sequencing-led intervention strategy for bacterial healthcare-associated infections for England and for the USA.Microbial genomics · 2023Article
- CamPype: an open-source workflow for automated bacterial whole-genome sequencing analysis focused on Campylobacter.BMC bioinformatics · 2023Article
- Metagenomic Antimicrobial Susceptibility Testing from Simulated Native Patient Samples.Antibiotics (Basel, Switzerland) · 2023Article
- Comparative genomic analysis of antibiotic resistance and virulence genes inFrontiers in cellular and infection microbiology · 2023Article
- Whole-Genome Sequencing Surveillance and Machine Learning of the Electronic Health Record for Enhanced Healthcare Outbreak Detection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- ESBL plasmids in Klebsiella pneumoniae: diversity, transmission and contribution to infection burden in the hospital setting.Genome medicine · 2022Article
- Using Genomics to Understand the Epidemiology of Infectious Diseases in the Northern Territory of Australia.Tropical medicine and infectious disease · 2022Review
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo predict the cost and health effects of routine use of whole-genome sequencing (WGS) of bacterial pathogens compared with those of standard of care.
designBudget impact analysis was performed over the following 5 years. Data were primarily from sequencing results on clusters of multidrug-resistant organisms across 27 hospitals. Model inputs were derived from hospitalisation and sequencing data, and epidemiological and costing reports, and included multidrug resistance rates and their trends.
settingQueensland, Australia.
participantsHospitalised patients.
interventionsWGS surveillance of six common multidrug-resistant organisms ( PRIMARY AND SECONDARY OUTCOMES: Expected hospital costs, counts of patient infections and colonisations, and deaths from bloodstream infections.
resultsIn 2021, 97 539 patients in Queensland are expected to be infected or colonised with one of six multidrug-resistant organisms with standard of care testing. WGS surveillance strategy and earlier infection control measures could avoid 36 726 infected or colonised patients and avoid 650 deaths. The total cost under standard of care was $A170.8 million in 2021. WGS surveillance costs an additional $A26.8 million but was offset by fewer costs for cleaning, nursing, personal protective equipment, shorter hospital stays and antimicrobials to produce an overall cost savings of $30.9 million in 2021. Sensitivity analyses showed cost savings remained when input values were varied at 95% confidence limits.
conclusionsCompared with standard of care, WGS surveillance at a state-wide level could prevent a substantial number of hospital patients infected with multidrug-resistant organisms and related deaths and save healthcare costs. Primary prevention through routine use of WGS is an investment priority for the control of serious hospital-associated infections.
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