Evidence map›Paper›PMID 33526169›Full record

RevieweLife2021

Gross ways to live long: Parasitic worms as an anti-inflammaging therapy?

Bruce Zhang, David Gems

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Immuno-therapeutic and prophylactic potential ofFood and waterborne parasitology · 2024
    Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
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  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Bruce ZhangInstitute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, United Kingdom.ORCID 0000-0003-0956-6142
David GemsInstitute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, United Kingdom.ORCID 0000-0002-6653-4676
MRC Unit for Lifelong Health and Ageing · GB

Funding

Wellcome Trust 098565/Z/12/ZWellcome Trust 215574Wellcome Trust 215574/Z/19/Z
6 · The paper itself

Abstract

Evolutionary medicine argues that disease can arise because modern conditions do not match those in which we evolved. For example, a decline in exposure to commensal microbes and gastrointestinal helminths in developed countries has been linked to increased prevalence of allergic and autoimmune inflammatory disorders (the hygiene hypothesis). Accordingly, probiotic therapies that restore 'old friend' microbes and helminths have been explored as Darwinian treatments for these disorders. A further possibility is that loss of old friend commensals also increases the sterile, aging-associated inflammation known as inflammaging, which contributes to a range of age-related diseases, including cardiovascular disease, dementia, and cancer. Interestingly, Crowe et al., 2020 recently reported that treatment with a secreted glycoprotein from a parasitic nematode can protect against murine aging by induction of anti-inflammatory mechanisms. Here, we explore the hypothesis that restorative helminth therapy would have anti-inflammaging effects. Could worm infections provide broad-spectrum protection against age-related disease?

Indexed as

ImmunosenescenceAgingAnimalsAutoimmune DiseasesHelminthiasisHelminthsHost-Parasite InteractionsHumansInflammationagingevolutionary medicinehelminth therapyhygiene hypothesisimmunologyinflammaginginflammationold friends

Identifiers

PMID33526169
PMCPMC7853715
OpenAlexW3126556566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.