Evidence map›Paper›PMID 33526063›Full record

ArticleMolecular brain2021

Further evidence that CP-AMPARs are critically involved in synaptic tag and capture at hippocampal CA1 synapses.

Pojeong Park, Heather Kang, John Georgiou, Min Zhuo, Bong-Kiun Kaang, Graham L Collingridge

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. The role of calcium stores in long-term potentiation and synaptic tagging and capture in mouse hippocampus.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Article
  3. Article
  4. Review
  5. Review
  6. Heterosynaptic plasticity-induced modulation of synapses.The journal of physiological sciences : JPS · 2023
    Review
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 4 countries.

Pojeong ParkSchool of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, 08826, Korea.
Heather KangDepartment of Physiology, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
John GeorgiouLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.
Min ZhuoSchool of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, 08826, Korea.
Bong-Kiun KaangSchool of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, 08826, Korea.
Graham L CollingridgeSchool of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, 08826, Korea. collingridge@lunenfeld.ca.ORCID 0000-0002-9572-5359
Mount Sinai Hospital · CASeoul National University · KRUniversity of Toronto · CA

Funding

CIHR 66975CIHR 84256CIHR FDN154276
6 · The paper itself

Abstract

The synaptic tag and capture (STC) hypothesis provides an important theoretical basis for understanding the synaptic basis of associative learning. We recently provided pharmacological evidence that calcium-permeable AMPA receptors (CP-AMPARs) are a crucial component of this form of heterosynaptic metaplasticity. Here we have investigated two predictions that arise on the basis of CP-AMPARs serving as a trigger of STC. Firstly, we compared the effects of the order in which we delivered a strong theta burst stimulation (TBS) protocol (75 pulses) and a weak TBS protocol (15 pulses) to two independent inputs. We only observed significant heterosynaptic metaplasticity when the strong TBS preceded the weak TBS. Second, we found that pausing stimulation following either the sTBS or the wTBS for ~20 min largely eliminates the heterosynaptic metaplasticity. These observations are consistent with a process that is triggered by the synaptic insertion of CP-AMPARs and provide a framework for establishing the underlying molecular mechanisms.

Indexed as

Cell Membrane PermeabilityAnimalsCA1 Region, HippocampalCalciumElectric StimulationMaleMiceMice, Inbred C57BLNeuronal PlasticityReceptors, AMPASynapsesTheta RhythmCalciumReceptors, AMPAHeterosynaptic plasticityLearningMemoryMetaplasticitySynapse specificitySynaptic efficacySynaptic potentiationSynaptic tag and capture

Identifiers

PMID33526063
PMCPMC7851922
OpenAlexW3126775162

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.