ArticleMolecular and cellular biology1988
A novel hsp70-like protein (P70) is present in mouse spermatogenic cells.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 92 citations in OpenAlex.
- Mechanisms of Hormonal, Genetic, and Temperature Regulation of Germ Cell Proliferation, Differentiation, and Death During Spermatogenesis.Biomolecules · 2025Review
- What's Genetic Variation Got to Do with It? Starvation-Induced Self-Fertilization Enhances Survival in Paramecium.Genome biology and evolution · 2020Article
- Analysis of Drosophila melanogaster testis transcriptome.BMC genomics · 2018Article
- Malfunction of spermatogenesis in experimental ischemic mice.The Journal of reproduction and development · 2015Article
- Reporter mice express green fluorescent protein at initiation of meiosis in spermatocytes.Genesis (New York, N.Y. : 2000) · 2014Article
- Molecular chaperones, cochaperones, and ubiquitination/deubiquitination system: involvement in the production of high quality spermatozoa.BioMed research international · 2014Review
- Mutation of Eif4g3, encoding a eukaryotic translation initiation factor, causes male infertility and meiotic arrest of mouse spermatocytes.Development (Cambridge, England) · 2010Article
- Development and application of a system for seminolipid metabolism using mouse seminiferous tubules.Glycoconjugate journal · 2010Article
- Hypomorphic mutation in an essential cell-cycle kinase causes growth retardation and impaired spermatogenesis.The EMBO journal · 2003Article
- Heat shock protein expression during gametogenesis and embryogenesis.Infectious diseases in obstetrics and gynecology · 1999Review
- Heat shock factor function and regulation in response to cellular stress, growth, and differentiation signals.Gene expression · 1999Review
- Expression of heat shock protein 70 blocks thymic differentiation of T cells in transgenic mice.Immunology · 1998Article
- Expression and sulfogalactolipid binding specificity of the recombinant testis-specific cognate heat shock protein 70.Glycoconjugate journal · 1997Article
- Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Chemical modifications of a recombinant bovine stress-inducible 70 kDa heat-shock protein (Hsp70) mimics Hsp70 isoforms from tissues.The Biochemical journal · 1995Article
- Genetic aspects of the hsp70 multigene family in vertebrates.Experientia · 1994Review
- Testis-specific mak protein kinase is expressed specifically in the meiotic phase in spermatogenesis and is associated with a 210-kilodalton cellular phosphoprotein.Molecular and cellular biology · 1993Article
- Characterization and inducibility of hsp 70 proteins in the male mouse germ line.The Journal of cell biology · 1990Article
- A 14 bp promoter element directs the testis specificity of the Drosophila beta 2 tubulin gene.The EMBO journal · 1989Article
- Expression of a testis-specific hsp70 gene-related RNA in defined stages of rat seminiferous epithelium.The Journal of cell biology · 1988Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mouse spermatogenic cells contain relatively large amounts of a 70-kilodalton protein (P70) that is closely related to hsp70, the major inducible heat shock protein. When hsp70 from spermatogenic cells is heat induced, it migrates to the same location as does P70 on two-dimensional polyacrylamide gels, indicating that it has an apparently identical mass and isoelectric point. P70 reacts strongly and specifically with an anti-Drosophila hsp70 monoclonal antibody that is specific for products of the hsp70 gene family. Both P70 and hsp70 are also ATP-binding proteins and are purified by using ATP-affinity chromatography. However, P70 and hsp70 are unique proteins on the basis of peptide map analysis and are regulated differently in germ cells. P70 appears to be a novel heat shock protein of spermatogenic cells which is synthesized in association with germ cell differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.