ReviewAdipocyte2021
Fat grafting and platelet-rich plasma in wound healing: a review of histology from animal studies.
Review in Adipocyte, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Histological analysis of fat grafting with platelet-rich plasma for diabetic foot ulcers-A randomised controlled trial.International wound journal · 2022Trial
- Oil Droplet in Apoptotic Uniocular Adipocyte: A Double-Edged Sword in Determining Macrophage Phenotype and its Implications on Fat Grafting.Aesthetic plastic surgery · 2026Article
- T-PRP-DAT Gel: A Novel Material Promotes Adipose Tissue Regeneration.Journal of cosmetic dermatology · 2025Article
- A Novel Laboratory-Based Strategy for Single Adipocyte and Adipose-Derived Stem Cells Extraction for Transplantation: An Experimental Research.Aesthetic plastic surgery · 2025Article
- The Efficacy and Safety of Negative-Pressure Wound Therapy Combined With Platelet-Rich Plasma in Chronic Refractory Wounds: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Health science reports · 2024Review
- The effect of exogenous mitochondria in enhancing the survival and volume retention of transplanted fat tissue in a nude mice model.Stem cell research & therapy · 2024Article
- Clinical Study on the treatment of chronic infectious ulcers using Platelet-Rich technology combined with moist dressings.Pakistan journal of medical sciences · 2024Article
- Bronchoscopic management of bronchopleural fistula using free fat pad transplant with platelet-rich plasma: a case study.Journal of cardiothoracic surgery · 2024Article
- The fate of adipose tissue and adipose-derived stem cells in allograft.Cell and tissue research · 2023Review
- [Effects of three-dimensional bioprinting antibacterial hydrogel on full-thickness skin defect wounds in rats].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Article
- Substrate stiffness can affect the crosstalk between adipose derived mesenchymal stem cells and macrophages in bone tissue engineering.Frontiers in bioengineering and biotechnology · 2023Article
- Platelet-Rich Plasma Applications in Plastic Surgery.World journal of plastic surgery · 2023Article
- Function and mechanism of mesenchymal stem cells in the healing of diabetic foot wounds.Frontiers in endocrinology · 2023Review
- Restoring Prohealing/Remodeling-Associated M2a/c Macrophages Using ON101 Accelerates Diabetic Wound Healing.JID innovations : skin science from molecules to population health · 2022Article
- Stem Cells and Angiogenesis: Implications and Limitations in Enhancing Chronic Diabetic Foot Ulcer Healing.Cells · 2022Review
- The Combined Use of Platelet-Rich Plasma and Adipose-Derived Mesenchymal Stem Cells Promotes Healing. A Review of Experimental Models and Future Perspectives.Biomolecules · 2021Review
- Combining Biocompatible and Biodegradable Scaffolds and Cold Atmospheric Plasma for Chronic Wound Regeneration.International journal of molecular sciences · 2021Review
- Autologous fat grafting and adipose-derived stem cells therapy for acute burns and burn-related scar: A systematic review.Tzu chi medical journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stem cells could form the basis of a novel, autologous treatment for chronic wounds like diabetic foot ulcers. Fat grafts contain adipose-derived stem cells (ADSC) but low survival of cells within the grafts is a major limitation. Platelet-rich plasma (PRP) may increase graft survival. This review examines the histology from animal studies on fat grafting, ADSC and PRP in wound healing. A literature review of major electronic databases was undertaken, and narrative synthesis performed. Data from 30 animal studies were included. ADSC increase angiogenesis over 14 days and often clinically accelerated wound healing. ADSC had a greater effect in animals with impaired wound healing (e.g. diabetes). Activated PRP increased viability of fat grafts. Despite the high number of studies, the quality is variable which weakens the evidence. It does suggest there is a benefit of ADSC, particularly in impaired wound healing. High-quality evidence in humans is required, to establish its clinical usefulness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.