Evidence map›Paper›PMID 33525785›Full record

ArticleEmerging topics in life sciences2018

Cryo-soft X-ray tomography: using soft X-rays to explore the ultrastructure of whole cells.

Maria Harkiolaki, Michele C Darrow, Matthew C Spink, Ewelina Kosior, Kyle Dent, Elizabeth Duke

Abstract read
In one paragraph

Article in Emerging topics in life sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

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  10. Towards a quantitative theory for transmission X-ray microscopy.Beilstein journal of nanotechnology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maria HarkiolakiDiamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, U.K.
Michele C DarrowDiamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, U.K.
Matthew C SpinkDiamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, U.K.
Ewelina KosiorDiamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, U.K.
Kyle DentDiamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, U.K.
Elizabeth DukeDiamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, U.K.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cryo-soft X-ray tomography is an imaging technique that addresses the need for mesoscale imaging of cellular ultrastructure of relatively thick samples without the need for staining or chemical modification. It allows the imaging of cellular ultrastructure to a resolution of 25-40 nm and can be used in correlation with other imaging modalities, such as electron tomography and fluorescence microscopy, to further enhance the information content derived from biological samples. An overview of the technique, discussion of sample suitability and information about sample preparation, data collection and data analysis is presented here. Recent developments and future outlook are also discussed.

Identifiers

PMID33525785
PMCPMC7289011

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.