Evidence map›Paper›PMID 33525680›Full record

ArticleInternational journal of molecular sciences2021

Effective Activation by Kynurenic Acid and Its Aminoalkylated Derivatives on M-Type K

Yi-Ching Lo, Chih-Lung Lin, Wei-Yu Fang, Bálint Lőrinczi, István Szatmári, Wan-Hsuan Chang, Ferenc Fülöp, Sheng-Nan Wu

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Evaluation of Small-Molecule Candidates as Modulators of M-Type KInternational journal of molecular sciences · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Evidence for Dual Activation ofInternational journal of molecular sciences · 2022
    Article
  11. The Effectiveness in Activating M-Type KInternational journal of molecular sciences · 2021
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yi-Ching LoDepartment of Pharmacology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.ORCID 0000-0003-1745-655X
Chih-Lung LinDepartment of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
Wei-Yu FangDepartment of Pharmacology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Bálint LőrincziInstitute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
István SzatmáriInstitute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.ORCID 0000-0002-8571-5229
Wan-Hsuan ChangDepartment of Pharmacology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Ferenc FülöpInstitute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.ORCID 0000-0003-1066-5287
Sheng-Nan WuInstitute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan City 70101, Taiwan.ORCID 0000-0002-5208-3253
Kaohsiung Medical University · TWUniversity of Szeged · HUNational Cheng Kung University · TW

Funding

Ministry of Science and Technology, Taiwan MOST-108-2314-B-006-094Ministry of Science and Technology, Taiwan MOST-108-2320-B-037-019-MY3
6 · The paper itself

Abstract

Kynurenic acid (KYNA, 4-oxoquinoline-2-carboxylic acid), an intermediate of the tryptophan metabolism, has been recognized to exert different neuroactive actions; however, the need of how it or its aminoalkylated amide derivative

Indexed as

AnimalsApaminCell LineHippocampusIndolesKCNQ Potassium ChannelsKynurenic AcidMembrane PotentialsMicePatch-Clamp TechniquesPeptidesPyridinesRatsApaminiberiotoxinIndolesKCNQ Potassium ChannelsKynurenic AcidlinopirdinePeptidesPyridinesaction potentialhippocampal neuronkynurenic acidkynurenic acid derivativeM-type K+ currentpituitary cell

Identifiers

PMID33525680
PMCPMC7865226
OpenAlexW3123437182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.