Evidence map›Paper›PMID 33525653›Full record

ArticleNutrients2021

Analytical Performance Specifications for 25-Hydroxyvitamin D Examinations.

Etienne Cavalier, Callum G Fraser, Harjit P Bhattoa, Annemieke C Heijboer, Konstantinos Makris, Candice Z Ulmer, Hubert W Vesper, Samuel Vasikaran, Pierre Lukas, Pierre Delanaye and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 9 countries.

Etienne CavalierCHU de Liège and Centre de Recherche Intégré sur les Médicaments (CIRM), Department of Clinical Chemistry, University of Liège, Domaine du Sart-Tilman, B-4000 Liège, Belgium.ORCID 0000-0003-0947-2226
Callum G FraserCentre for Research into Cancer Prevention and Screening, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.ORCID 0000-0002-1333-7994
Harjit P BhattoaDepartment of Laboratory Medicine, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.ORCID 0000-0002-4909-0065
Annemieke C HeijboerEndocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology & Metabolism, Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam UMC, 1081 HVAmsterdam, The Netherlands.
Konstantinos MakrisClinical Biochemistry Department, KAT General Hospital, GR-14561 Athens, Greece.ORCID 0000-0002-7896-9028
Candice Z UlmerNational Center for Environmental Health, Centers for Disease Control and Prevention, Division of Laboratory Sciences, Atlanta, GA 30329, USA.ORCID 0000-0003-1477-6873
Hubert W VesperNational Center for Environmental Health, Centers for Disease Control and Prevention, Division of Laboratory Sciences, Atlanta, GA 30329, USA.
Samuel VasikaranPathWest Laboratory Medicine, Fiona Stanley Hospital, Murdoch 6150, Australia.
Pierre LukasCHU de Liège and Centre de Recherche Intégré sur les Médicaments (CIRM), Department of Clinical Chemistry, University of Liège, Domaine du Sart-Tilman, B-4000 Liège, Belgium.ORCID 0000-0002-1071-9057
Pierre DelanayeDepartment of Nephrology, Dialysis and Transplantation, University of Liege, CHU de Liege, B-4000 Liège, Belgium.
Anna CarobeneLaboratory Medicine, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.ORCID 0000-0003-0147-9378
On Behalf Of The Ifcc-Iof Committee For Bone Metabolism
University of Liège · BECenters for Disease Control and Prevention · USAmsterdam University Medical Centers · NLFiona Stanley Hospital · AUKAT General Hospital of Attica · GRUniversity of Debrecen · HUUniversity of Dundee · GBVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently the 25-hydroxy vitamin D (25(OH)D) concentration is thought to be the best estimate of the vitamin D status of an individual. Unfortunately, its measurement remains complex, despite recent technological advances. We evaluated the biological variation (BV) of 25(OH)D in order to set analytical performance specifications (APS) for measurement uncertainty (MU). Six European laboratories recruited 91 healthy participants. The 25(OH)D concentrations in K

Indexed as

Blood Specimen CollectionHumansLinear ModelsModels, TheoreticalUncertaintyVitamin D25-hydroxyvitamin DVitamin D25(OH)-vitamin Danalytical performance specifications biological variationmeasurement uncertaintyvitamin D

Identifiers

PMID33525653
PMCPMC7911223
OpenAlexW3122649889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.