Evidence map›Paper›PMID 33525644›Full record

ArticleInternational journal of molecular sciences2021

Effect of O-Antigen Chain Length Regulation on the Immunogenicity of

Gianmarco Gasperini, Maria Michelina Raso, Vanessa Arato, Maria Grazia Aruta, Paola Cescutti, Francesca Necchi, Francesca Micoli

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. A multifunctional anti-O-Antigen human monoclonal antibody protects againstProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Review
  6. Frontiers in cellular and infection microbiology · 2024
    Article
  7. Article
  8. Development of themSphere · 2023
    Article
  9. Toward aInternational journal of molecular sciences · 2023
    Review
  10. Article
  11. Article
  12. Comparison ofFrontiers in molecular biosciences · 2023
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Impact of O-Acetylation onMicroorganisms · 2021
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Gianmarco GasperiniGSK Vaccines Institute for Global Health (GVGH) s.r.l, Via Fiorentina 1, 53100 Siena, Italy.
Maria Michelina RasoGSK Vaccines Institute for Global Health (GVGH) s.r.l, Via Fiorentina 1, 53100 Siena, Italy.ORCID 0000-0001-6183-965X
Vanessa AratoGSK Vaccines Institute for Global Health (GVGH) s.r.l, Via Fiorentina 1, 53100 Siena, Italy.
Maria Grazia ArutaGSK Vaccines Institute for Global Health (GVGH) s.r.l, Via Fiorentina 1, 53100 Siena, Italy.
Paola CescuttiDepartment of Life Sciences, University of Trieste, Via L. Giorgieri 1, Bdg C11, 34127 Trieste, Italy.ORCID 0000-0003-3744-2198
Francesca NecchiGSK Vaccines Institute for Global Health (GVGH) s.r.l, Via Fiorentina 1, 53100 Siena, Italy.
Francesca MicoliGSK Vaccines Institute for Global Health (GVGH) s.r.l, Via Fiorentina 1, 53100 Siena, Italy.
Toscana Life Sciences · ITUniversity of Trieste · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, generalized modules for membrane antigens (GMMA) technology has been proposed as an alternative approach to traditional glycoconjugate vaccines for O-antigen delivery. Saccharide length is a well-known parameter that can impact the immune response induced by glycoconjugates both in terms of magnitude and quality. However, the criticality of O-antigen length on the immune response induced by GMMA-based vaccines has not been fully elucidated. Here,

Indexed as

AnimalsAntibodies, BacterialBacterial VaccinesDrug DesignGenetic EngineeringImmunizationMiceMice, NudeMutationO AntigensSalmonella typhimuriumSerumShigella flexneriShigella sonneiT-LymphocytesAntibodies, BacterialBacterial VaccinesO AntigensGMMAO-antigensaccharide lengthSalmonellaShigellaT-independentvaccine

Identifiers

PMID33525644
PMCPMC7865430
OpenAlexW3121140385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.