Evidence map›Paper›PMID 33525621›Full record

ArticleMolecules (Basel, Switzerland)2021

Synthesis of Novel Tryptamine Derivatives and Their Biological Activity as Antitumor Agents.

Giorgia Simonetti, Carla Boga, Joseph Durante, Gabriele Micheletti, Dario Telese, Paolo Caruana, Andrea Ghelli Luserna di Rorà, Fabio Mantellini, Samantha Bruno, Giovanni Martinelli and 1 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Effects of tryptamine on duckweed growth.Frontiers in plant science · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Giorgia SimonettiBiosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori"-IRST S.r.l., 47014 Meldola (FC), Italy.ORCID 0000-0001-6954-969X
Carla BogaDepartment of Industrial Chemistry "Toso Montanari", Alma Mater Studiorum-Università di Bologna, Viale del Risorgimento 4, 40136 Bologna, Italy.ORCID 0000-0003-2851-8939
Joseph DuranteDepartment of Biomolecular Sciences, University of Urbino "Carlo Bo", Via I Maggetti 24, 61029 Urbino (PU), Italy.
Gabriele MichelettiDepartment of Industrial Chemistry "Toso Montanari", Alma Mater Studiorum-Università di Bologna, Viale del Risorgimento 4, 40136 Bologna, Italy.ORCID 0000-0001-9746-2356
Dario TeleseDepartment of Industrial Chemistry "Toso Montanari", Alma Mater Studiorum-Università di Bologna, Viale del Risorgimento 4, 40136 Bologna, Italy.ORCID 0000-0001-9372-0207
Paolo CaruanaDepartment of Industrial Chemistry "Toso Montanari", Alma Mater Studiorum-Università di Bologna, Viale del Risorgimento 4, 40136 Bologna, Italy.
Andrea Ghelli Luserna di RoràBiosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori"-IRST S.r.l., 47014 Meldola (FC), Italy.
Fabio MantelliniDepartment of Biomolecular Sciences, University of Urbino "Carlo Bo", Via I Maggetti 24, 61029 Urbino (PU), Italy.
Samantha BrunoDepartment of Experimental, Diagnostic and Specialty Medicine, Institute of Hematology and Medical Oncology "L. and A. Seràgnoli", University of Bologna, 40138 Bologna, Italy.
Giovanni MartinelliBiosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori"-IRST S.r.l., 47014 Meldola (FC), Italy.ORCID 0000-0002-1025-4210
Natalia CalonghiDepartment of Pharmacy and Biotechnology, University of Bologna, 40121 Bologna, Italy.

Funding

Università di Bologna Alma Idea Junior Research Grant
6 · The paper itself

Abstract

We synthesized five novel tryptamine derivatives characterized by the presence of an azelayl chain or of a 1,1,1-trichloroethyl group, in turn connected to another heterocyclic scaffold. The combination of tryptamin-, 1,1,1-trichloroethyl- and 2-aminopyrimidinyl- moieties produced compound

Indexed as

Antineoplastic AgentsBiological FactorsCell Line, TumorDrug Screening Assays, AntitumorHT29 CellsHumansNeoplasmsTryptaminesAntineoplastic AgentsBiological FactorsTryptaminescancerchloralleukemiaspyrimidinetryptamine

Identifiers

PMID33525621
PMCPMC7865355

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.