Evidence map›Paper›PMID 33525598›Full record

ArticleJournal of clinical medicine2021

TRPM5 rs886277 Polymorphism Predicts Hepatic Fibrosis Progression in Non-Cirrhotic HCV-Infected Patients.

Salvador Resino, Amanda Fernández-Rodríguez, Daniel Pineda-Tenor, Ana Zaida Gómez-Moreno, Juan José Sánchez-Ruano, Tomas Artaza-Varasa, María José Muñoz-Gómez, Ana Virseda-Berdices, María Martín-Vicente, Isidoro Martínez and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Transient receptor potential channels inChannels (Austin, Tex.) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Salvador ResinoUnidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28222 Majadahonda, Spain.ORCID 0000-0001-8783-0450
Amanda Fernández-RodríguezUnidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28222 Majadahonda, Spain.ORCID 0000-0002-5110-2213
Daniel Pineda-TenorServicio de Laboratorio Clínico, Hospital de Antequera, 29200 Málaga, Spain.
Ana Zaida Gómez-MorenoServicio de Digestivo, Hospital Virgen de la Salud, 45004 Toledo, Spain.
Juan José Sánchez-RuanoServicio de Digestivo, Hospital Virgen de la Salud, 45004 Toledo, Spain.ORCID 0000-0003-0921-9239
Tomas Artaza-VarasaServicio de Digestivo, Hospital Virgen de la Salud, 45004 Toledo, Spain.
María José Muñoz-GómezUnidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28222 Majadahonda, Spain.ORCID 0000-0002-9244-4500
Ana Virseda-BerdicesUnidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28222 Majadahonda, Spain.
María Martín-VicenteUnidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28222 Majadahonda, Spain.ORCID 0000-0001-9148-1476
Isidoro MartínezUnidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28222 Majadahonda, Spain.ORCID 0000-0002-9949-9264
María A Jiménez-SousaUnidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28222 Majadahonda, Spain.
Instituto de Salud Carlos III · ESHospital Virgen de la Salud · ES

Funding

Instituto de Salud Carlos III CP14CIII/00010Instituto de Salud Carlos III CP17CIII/00007Instituto de Salud Carlos III PI20CIII/00004
6 · The paper itself

Abstract

background

methodsWe conducted a retrospective study of 208 non-cirrhotic patients with CHC, who had at least two liver stiffness measurements (LSM) with a separation of 12 months (baseline LSM (LSM1) and the last LSM (LSM2)). Two outcome variables were considered: (1) LSM2/LSM1 ratio; (2) cirrhosis progression (F4; LSM ≥ 12.5 kPa). DNA genotyping was done at the CeGen using a MassARRAY platform.

resultsThe follow-up time was similar irrespective of the rs886277 genotype (46.4 months in TT genotype, 46.4 months in CT genotype, and 49.2 months in CC genotype;

conclusions

Indexed as

chronic hepatitis Ccirrhosishepatic fibrosisliver stiffnessSNPsTRPM5

Identifiers

PMID33525598
PMCPMC7865714
OpenAlexW3125437580

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.