ReviewSensors (Basel, Switzerland)2021
Evaluating the Possibility of Translating Technological Advances in Non-Invasive Continuous Lactate Monitoring into Critical Care.
Review in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Electro-Thermally Controlled Active Mechanical Metamaterials with Programmable Stiffness and Nonreciprocity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Simultaneous Remote Non-Invasive Blood Glucose and Lactate Measurements by Mid-Infrared Passive Spectroscopic Imaging.Sensors (Basel, Switzerland) · 2025Article
- Lactate Provides Metabolic Substrate Support and Attenuates Ischemic Brain Injury in Mice, Revealed byBiomedicines · 2025Article
- A Comprehensive Review of Advanced Lactate Biosensor Materials, Methods, and Applications in Modern Healthcare.Sensors (Basel, Switzerland) · 2025Review
- Recent Advances in Amperometric Biosensors for Medical Applications: A Mini-Review.Current topics in medicinal chemistry · 2025Review
- Advanced Wearable Devices for Monitoring Sweat Biochemical Markers in Athletic Performance: A Comprehensive Review.Biosensors · 2024Review
- Peroxidase-like Nanoparticles of Noble Metals Stimulate Increasing Sensitivity of FlavocytochromeBiosensors · 2024Article
- More Than One Enzyme: Exploring Alternative FMN-Dependent L-Lactate Oxidases for Biosensor Development.ACS omega · 2024Article
- Continuous and Non-Invasive Lactate Monitoring Techniques in Critical Care Patients.Biosensors · 2024Review
- Disposable Polyaniline/Polymers · 2024Article
- Wearable device for continuous sweat lactate monitoring in sports: a narrative review.Frontiers in physiology · 2024Review
- Real-Time Monitoring of Antibiotics in the Critically Ill Using Biosensors.Antibiotics (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lactate is widely measured in critically ill patients as a robust indicator of patient deterioration and response to treatment. Plasma concentrations represent a balance between lactate production and clearance. Analysis has typically been performed with the aim of detecting tissue hypoxia. However, there is a diverse range of processes unrelated to increased anaerobic metabolism that result in the accumulation of lactate, complicating clinical interpretation. Further, lactate levels can change rapidly over short spaces of time, and even subtle changes can reflect a profound change in the patient's condition. Hence, there is a significant need for frequent lactate monitoring in critical care. Lactate monitoring is commonplace in sports performance monitoring, given the elevation of lactate during anaerobic exercise. The desire to continuously monitor lactate in athletes has led to the development of various technological approaches for non-invasive, continuous lactate measurements. This review aims firstly to reflect on the potential benefits of non-invasive continuous monitoring technology within the critical care setting. Secondly, we review the current devices used to measure lactate non-invasively outside of this setting and consider the challenges that must be overcome to allow for the translation of this technology into intensive care medicine. This review will be of interest to those developing continuous monitoring sensors, opening up a new field of research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.