ReviewNutrients2021
The Role of Fetal, Infant, and Childhood Nutrition in the Timing of Sexual Maturation.
Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Age at menarche in South Asia: an interplay of sociodemographic, nutritional, lifestyle, anthropometric, biological, and environmental factors-a systematic review.Frontiers in public health · 2026Pooled it
- Comparison of central precocious puberty frequency before and during COVID-19: a systematic review and meta-analysis.BMC endocrine disorders · 2024Pooled it
- Terrestrial Animal Source Foods and Health Outcomes for Those with Special Nutrient Needs in the Life Course.Nutrients · 2024Pooled it
- Prevalence and factors associated with small for gestational age births among women delivering at a tertiary hospital in South-Western Uganda: a cross-sectional study.BMC pregnancy and childbirth · 2025Article
- Clinical determinants of time to full enteral feeding in preterm infants with neonatal respiratory distress syndrome: a retrospective cohort study.BMC pediatrics · 2025Article
- Weight Gain in Infancy and Childhood Were Associated With Pubertal Development in Boys and Girls.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Ramadan During Pregnancy and Offspring Age at Menarche in Indonesia: A Quasi-Experimental Study.Nutrients · 2025Article
- Analysis of Tanner stage in children conceived after the diagnosis of infertility: the DESCRT study.Journal of assisted reproduction and genetics · 2025Article
- The study of pubertal stage and age of menarche in girls in Isfahan province, Iran.BMC pediatrics · 2025Article
- Impact of Small-Quantity Lipid-Based Nutrient Supplements on Pubertal Status of 9-13-Year Olds: A Follow-Up Study of the iLiNS-DYAD-Ghana Trial.Current developments in nutrition · 2024Article
- Evaluating Phthalates and Bisphenol in Foods: Risks for Precocious Puberty and Early-Onset Obesity.Nutrients · 2024Review
- High Fat Diet and Polycystic Ovary Syndrome (PCOS) in Adolescence: An Overview of Nutritional Strategies.Nutrients · 2024Review
- Editorial: Nutrition, diet and endocrinological health in female children and adolescents.Frontiers in nutrition · 2024Article
- How the intricate relationship between nutrition and hormonal equilibrium significantly influences endocrine and reproductive health in adolescent girls.Frontiers in nutrition · 2024Article
- Breast and Formula Milk and Early Puberty Onset.Children (Basel, Switzerland) · 2023Review
- Molecular Genomic Study of Inhibin Molecule Production through Granulosa Cell Gene Expression in Inhibin-Deficient Mice.Molecules (Basel, Switzerland) · 2022Article
- The effects of the covid-19 pandemic on puberty: a cross-sectional, multicenter study from Turkey.Italian journal of pediatrics · 2022Article
- The establishment of the gut microbiota in 1-year-aged infants: from birth to family food.European journal of nutrition · 2022Observational
- Early programming of reproductive health and fertility: novel neuroendocrine mechanisms and implications in reproductive medicine.Human reproduction update · 2022Review
- Genetic, epigenetic and enviromental influencing factors on the regulation of precocious and delayed puberty.Frontiers in endocrinology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Puberty is a crucial developmental stage in the life span, necessary to achieve reproductive and somatic maturity. Timing of puberty is modulated by and responds to central neurotransmitters, hormones, and environmental factors leading to hypothalamic-pituitary-gonadal axis maturation. The connection between hormones and nutrition during critical periods of growth, like fetal life or infancy, is fundamental for metabolic adaptation response and pubertal development control and prediction. Since birth weight is an important indicator of growth estimation during fetal life, restricted prenatal growth, such as intrauterine growth restriction (IUGR) and small for gestational age (SGA), may impact endocrine system, affecting pubertal development. Successively, lactation along with early life optimal nutrition during infancy and childhood may be important in order to set up timing of sexual maturation and provide successful reproduction at a later time. Sexual maturation and healthy growth are also influenced by nutrition requirements and diet composition. Early nutritional surveillance and monitoring of pubertal development is recommended in all children, particularly in those at risk, such as the ones born SGA and/or IUGR, as well as in the case of sudden weight gain during infancy. Adequate macro and micronutrient intake is essential for healthy growth and sexual maturity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.