ArticleChildren (Basel, Switzerland)2021
Familial and Genetic Influences on the Common Pediatric Primary Pain Disorders: A Twin Family Study.
Article in Children (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Adolescent pain reports share genetic overlap with adult chronic pain conditions: A polygenic score analysis using the ABCD study.The journal of pain · 2026Article
- Co-occurring pediatric chronic pain and mental health: A genetically informed study.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Risk factors associated with growth pain disorder in children: a systematic review and meta-analysis.Frontiers in pediatrics · 2026Review
- Genetic and Environmental Associations Among Pain, Sleep Disturbances, and Substance Use Intent in Early Adolescence.Journal of adolescence · 2026Article
- Vagally Mediated Heart Rate Variability and Attachment-Related Avoidance in Pediatric Migraine: A Mediated Pathway to Somatic Symptoms Severity.Children (Basel, Switzerland) · 2025Article
- Long-term back pain recall in Generation XXI adolescents: the role of sensitivity and pain history.Pain reports · 2025Article
- Attrition from Face-to-Face Pediatric Outpatient Chronic Pain Interventions: A Narrative Review and Theoretical Model.Children (Basel, Switzerland) · 2024Review
- Determinants of sleep disturbance and sleep quality in children of mothers with fibromyalgia.Archives of rheumatology · 2023Article
- Back Pain without Disease or Substantial Injury in Children and Adolescents: A Twin Family Study Investigating Genetic Influence and Associations.Children (Basel, Switzerland) · 2023Article
- Primary dysmenorrhoea in adolescents and young women: A twin family study of maternal transmission, genetic influence and associations.The Australian & New Zealand journal of obstetrics & gynaecology · 2022Article
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Authors and funding
9 authors.
Funding
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Abstract
The primary pain disorders of childhood are highly prevalent but have infrequently been studied collectively. Genetic influences have been suggested to be causally implicated. Surveys were sent to 3909 Australian twin families, assessing the lifetime prevalence of growing pains, migraine, headache, recurrent abdominal pain, low back pain, and persistent pain (not otherwise specified) in pediatric twins and their immediate family members. Comparisons between monozygous (MZ) and dizygous (DZ) twin pair correlations, concordances and odds ratios were performed to assess the contribution of additive genetic influences. Random-effects logistic regression modelling was used to evaluate relationships between twin individuals and their co-twins, mothers, fathers and oldest siblings with the subject conditions. Twin analyses of responses from 1016 families revealed significant influence of additive genetic effects on the presence of growing pains, migraine, and recurrent abdominal pain. The analyses for headache, low back pain, and persistent pain overall did not conclusively demonstrate that genetic influences were implicated more than shared environmental factors. Regression analyses demonstrated varying levels of significance in relationships between family members and twin individuals for the tested conditions, with strongest support for genetic influences in growing pains and migraine. These data, together with previously published association analyses, suggest common causal influences including genes.
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