ArticleBrain sciences2021
Do Pregnancy-Induced Brain Changes Reverse? The Brain of a Mother Six Years after Parturition.
Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 82 citations in OpenAlex.
- Puberty, pregnancy, and menopause show shared and distinct structural changes across the lifespan.Nature communications · 2026Article
- Effect of Parity and β-Amyloid on Cognition and Hippocampal Volume in Postmenopausal Women.Neurology · 2026Article
- Early Adulthood Signatures of Motherhood in Brain Aging.Human brain mapping · 2026Article
- Maternal experience alters brain-wide representation of infant cries.bioRxiv : the preprint server for biology · 2026Article
- Ectogenesis, gestational preferences and the social coercion argument.Monash bioethics review · 2026Article
- Article
- Prenatal folic acid supplementation improves long-term postnatal maternal cognitive performance: findings from a cohort study.BMC pregnancy and childbirth · 2026Article
- Maternal brain alterations based on neurotransmitter and hormone receptor distributions over six months postpartum.Translational psychiatry · 2026Article
- The PMADS Project: A Longitudinal Multimodal Cohort Study to Understand Risk for Perinatal Mood and Anxiety Disorders.bioRxiv : the preprint server for biology · 2026Article
- Traces of Parenthood but Not Pregnancy Loss in UK Biobank Structural Brain MRI Data.Human brain mapping · 2026Article
- The effects of a second pregnancy on women's brain structure and function.Nature communications · 2026Article
- Psychedelic therapy and postpartum depression: priorities and prospects.Therapeutic advances in psychopharmacology · 2026Review
- Sleep, physical activity, and pregnancy symptoms: Factors associated with cognitive performance in early pregnancy.Midwifery · 2025Article
- Did Down-Regulated Instincts Enable Human Gene-Culture Coevolution?Evolutionary anthropology · 2025Review
- Persistent dopamine-dependent remodeling of the neural transcriptome in response to pregnancy and postpartum.bioRxiv : the preprint server for biology · 2025Article
- Sex differences in age-associated neurological diseases-A roadmap for reliable and high-yield research.Science advances · 2025Review
- Preconceptional brain structure and future conception: a prospective brain MRI study among 321 women.Scientific reports · 2025Article
- Longitudinal investigation of neurobiological changes across pregnancy.Communications biology · 2025Article
- Pregnancy entails a U-shaped trajectory in human brain structure linked to hormones and maternal attachment.Nature communications · 2025Article
- Longitudinal neuroanatomical increases from early to one-year postpartum.Brain structure & function · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 11 institutions in 2 countries.
Funding
Abstract
Neuroimaging researchers commonly assume that the brain of a mother is comparable to that of a nulliparous woman. However, pregnancy leads to pronounced gray matter volume reductions in the mother's brain, which have been associated with maternal attachment towards the baby. Beyond two years postpartum, no study has explored whether these brain changes are maintained or instead return to pre-pregnancy levels. The present study tested whether gray matter volume reductions detected in primiparous women are still present six years after parturition. Using data from a unique, prospective neuroimaging study, we compared the gray matter volume of 25 primiparous and 22 nulliparous women across three sessions: before conception (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.