Evidence map›Paper›PMID 33525455›Full record

ArticleBiomolecules2021

The α6 GABA

Roberto Cadeddu, Daniel E Knutson, Laura J Mosher, Stefanos Loizou, Karen Odeh, Janet L Fisher, James M Cook, Marco Bortolato

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Activation of MBritish journal of pharmacology · 2024
    Article
  2. Why Can Modulation of α6-Containing GABAArchives of pharmacology and therapeutics · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Tics: neurological disorders determined by a deficit in sensorimotor gating processes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Review
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Roberto CadedduDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 84112, USA.
Daniel E KnutsonDepartment of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA.ORCID 0000-0002-8043-767X
Laura J MosherDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 84112, USA.
Stefanos LoizouDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 84112, USA.
Karen OdehDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 84112, USA.
Janet L FisherDepartment of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, Columbia, SC 29209, USA.
James M CookDepartment of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA.ORCID 0000-0001-5512-3022
Marco BortolatoDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-4498-9637
University of Utah · USUniversity of Wisconsin–Milwaukee · USUniversity of South Carolina · US

Funding

Exploring the role of neurosteroids in tic modulationR21NS108722 · NINDS · UNIVERSITY OF UTAH · PI BORTOLATO, MARCO, PITTENGER, CHRISTOPHER JOHN · 2018 to 2019
$428k
NIH HHS R21 NS108722
6 · The paper itself

Abstract

Tourette syndrome (TS) is a disabling neurodevelopmental disorder characterized by multiple, recurrent tics. The pharmacological treatment of TS is currently based on dopaminergic antagonists; however, these drugs are associated with extrapyramidal symptoms and other serious adverse events. Recent evidence suggests that positive allosteric modulators (PAMs) of GABA

Indexed as

Behavior, AnimalAnimalsBenzazepinesBlinkingCataplexyDisease Models, AnimalDopamineMiceMice, Inbred C57BLMice, TransgenicPrefrontal CortexReceptors, GABA-AReflex, StartleTicsTourette SyndromeBenzazepinesDopamineGabra6 protein, mouseReceptors, GABA-ASK&F 82958DK-I-56-1GABAA receptorspontaneous eyeblinksticsTourette syndrome

Identifiers

PMID33525455
PMCPMC7912006
OpenAlexW3125042978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.