Evidence map›Paper›PMID 33525417›Full record

ReviewInternational journal of molecular sciences2021

The Role of GSH in Intracellular Iron Trafficking.

Robert Hider, Mayra Vera Aviles, Yu-Lin Chen, Gladys Oluyemisi Latunde-Dada

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. HIV-1 gp120-induced lysosomal stress responses are controlled by TRPML1 redox sensors.Redox report : communications in free radical research · 2026
    Article
  2. Article
  3. Article
  4. ABCC1 promotes GSH-dependent iron transport and resistance to Fe(II) and Cu(II) chelators.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. The Labile Side of Iron in Health and Disease: A Narrative Review.Advances in experimental medicine and biology · 2025
    Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Iron Homeostasis inBiology · 2023
    Review
  16. Article
  17. Natural Compounds and Glutathione: Beyond Mere Antioxidants.Antioxidants (Basel, Switzerland) · 2023
    Review
  18. Labile Iron Pool of IsolatedJournal of the American Chemical Society · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Robert HiderInstitute of Pharmaceutical Science, King's College London, London SE1 9NH, UK.
Mayra Vera AvilesInstitute of Pharmaceutical Science, King's College London, London SE1 9NH, UK.
Yu-Lin ChenInstitute of Pharmaceutical Science, King's College London, London SE1 9NH, UK.
Gladys Oluyemisi Latunde-DadaInstitute of Pharmaceutical Science, King's College London, London SE1 9NH, UK.ORCID 0000-0002-0607-6909

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence is reviewed for the role of glutathione in providing a ligand for the cytosolic iron pool. The possibility of histidine and carnosine forming ternary complexes with iron(II)glutathione is discussed and the physiological significance of these interactions considered. The role of carnosine in muscle, brain, and kidney physiology is far from established and evidence is presented that the iron(II)-binding capability of carnosine relates to this role.

Indexed as

BrainCarnosineDNA-Binding ProteinsGene Expression RegulationGlutathioneHistidineHumansHydrogen-Ion ConcentrationHypoxia-Inducible Factor 1, alpha SubunitIronIron Chelating AgentsIron Regulatory Protein 1Iron Regulatory Protein 2KidneyMitochondriaMusclesACO1 protein, humanCarnosineDNA-Binding ProteinsGlutathioneHIF1A protein, humanHistidineHypoxia-Inducible Factor 1, alpha SubunitIREB2 protein, humanIronIron Chelating AgentsIron Regulatory Protein 1Iron Regulatory Protein 2PCBP1 protein, humanRNA-Binding Proteinscarnosinecytosolglutathionehistidinelabile iron

Identifiers

PMID33525417
PMCPMC7865746

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.