ArticleMolecules (Basel, Switzerland)2021
Chloroquine and Hydroxychloroquine Interact Differently with ACE2 Domains Reported to Bind with the Coronavirus Spike Protein: Mediation by ACE2 Polymorphism.
Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
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- Green synthesis of plant-derived ZnO nanoparticles: Characterization, pharmacokinetics, molecular interactions, andBiomolecules & biomedicine · 2025Article
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- Impact of COVID-19 on breast cancer patients and services in a UK region: Protocol for a mixed methods study.PloS one · 2025Article
- Burden of SARS-CoV-2 infection and severe illness in South Africa (March 2020-August 2022): a synthesis of epidemiological data.BMJ public health · 2025Article
- Anti-Vasculogenic, Antioxidant, and Anti-Inflammatory Activities of Sulfated Polysaccharide Derived fromPharmaceuticals (Basel, Switzerland) · 2024Article
- Genetic Variants within SARS-CoV-2 Human Receptor Genes May Contribute to Variable Disease Outcomes in Different Ethnicities.International journal of molecular sciences · 2023Review
- Chemical Composition ofMetabolites · 2022Article
- Physiological Responses of the BivalvesAnimals : an open access journal from MDPI · 2022Article
- Phytochemical Composition, Antioxidant, and Anticancer Activities of Sidr Honey: In Vitro and In Silico Computational Investigation.Life (Basel, Switzerland) · 2022Article
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- Attenuation of ovalbumin-induced inflammation and lung oxidative injury in asthmatic rats by3 Biotech · 2022Article
- Pharmacokinetics and Therapeutic Potential ofLife (Basel, Switzerland) · 2022Article
- Kidney injury and oxidative damage alleviation by3 Biotech · 2022Article
- Expression Profiling of Selected Immune Genes and Trabecular Microarchitecture in Breast Cancer Skeletal Metastases Model: Effect of α-Tocopherol Acetate Supplementation.Calcified tissue international · 2022Article
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- Antiviral Effects of Artemisinin and Its Derivatives against SARS-CoV-2 Main Protease: Computational Evidences and Interactions with ACE2 Allelic Variants.Pharmaceuticals (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection inducing coronavirus disease 2019 (COVID-19) is still an ongoing challenge. To date, more than 95.4 million have been infected and more than two million deaths have been officially reported by the WHO. Angiotensin-converting enzyme (ACE) plays a key role in the disease pathogenesis. In this computational study, seventeen coding variants were found to be important for ACE2 binding with the coronavirus spike protein. The frequencies of these allele variants range from 3.88 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.