Evidence map›Paper›PMID 33525361›Full record

ArticleCancers2021

The Immunoscore in Localized Urothelial Carcinoma Treated with Neoadjuvant Chemotherapy: Clinical Significance for Pathologic Responses and Overall Survival.

Elise F Nassif, Bernhard Mlecnik, Constance Thibault, Marie Auvray, Daniela Bruni, Alexandre Colau, Eva Compérat, Gabriela Bindea, Aurélie Catteau, Aurélie Fugon and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 8 institutions in 2 countries.

Elise F NassifOncology Department, Hopital Européen Georges Pompidou, University of Paris, 75015 Paris, France.
Bernhard MlecnikCentre de Recherche des Cordeliers, Laboratory of Integrative Cancer Immunology, INSERM, Université de Paris, 75015 Paris, France.ORCID 0000-0002-3345-1030
Constance ThibaultOncology Department, Hopital Européen Georges Pompidou, University of Paris, 75015 Paris, France.
Marie AuvrayOncology Department, Hopital Européen Georges Pompidou, University of Paris, 75015 Paris, France.
Daniela BruniCentre de Recherche des Cordeliers, Laboratory of Integrative Cancer Immunology, INSERM, Université de Paris, 75015 Paris, France.ORCID 0000-0003-2015-3891
Alexandre ColauUrology Department, Diaconnesses Hospital, 75020 Paris, France.
Eva CompératPathology Department, Diaconnesses Hospital, 75012 Paris, France.
Gabriela BindeaCentre de Recherche des Cordeliers, Laboratory of Integrative Cancer Immunology, INSERM, Université de Paris, 75015 Paris, France.
Aurélie CatteauHalioDx, 13009 Marseille, France.
Aurélie FugonHalioDx, 13009 Marseille, France.
Isabelle BoquetHalioDx, 13009 Marseille, France.
Marine MartelHalioDx, 13009 Marseille, France.
Philippe CamparoCentre de Pathologie, 80000 Amiens, France.
Pierre ColinUrology Department, La Louvière, 59042 Lille, France.
Roubini ZakopoulouOncology Department, Alexandra Hospital, 11528 Athens, Greece.ORCID 0000-0001-8301-8879
Aristotelis BamiasOncology Department, Alexandra Hospital, 11528 Athens, Greece.ORCID 0000-0002-5996-7262
Mostefa BennamounOncology Department, Institut Mutualiste Montsouris, 75014 Paris, France.
Xavier BarthereOncology Department, Institut Mutualiste Montsouris, 75014 Paris, France.
Bruno D'acremontUrology Department, Clinique St Jean De Dieu, 75007 Paris, France.
Marine LefevreDepartment of Pathology, Institut Mutualiste Montsouris, 75014 Paris, France.
Francois AudenetUrology Department, Hopital Européen Georges Pompidou, AP-HP-Université de Paris, 75015 Paris, France.ORCID 0000-0001-5722-2075
Arnaud MejeanPathology Department, Hopital Européen Georges Pompidou, 75015 Paris, France.ORCID 0000-0003-2280-9516
Virginie VerkarreUrology Department, Hopital Européen Georges Pompidou, AP-HP-Université de Paris, 75015 Paris, France.
Stéphane OudardOncology Department, Hopital Européen Georges Pompidou, University of Paris, 75015 Paris, France.
Jérôme GalonCentre de Recherche des Cordeliers, Laboratory of Integrative Cancer Immunology, INSERM, Université de Paris, 75015 Paris, France.
Université Paris Cité · FRInserm · FRInstitute Mutualiste Montsouris · FRAlexandra Hospital · GRHôpital des Diaconesses · FRCentre Hospitalier Universitaire Amiens-Picardie · FRClinique Saint Jean Languedoc · FRHôpital Européen Georges-Pompidou · FR

Funding

FONCER 5
6 · The paper itself

Abstract

(1) Background-The five-year overall survival (OS) of muscle-invasive bladder cancer (MIBC) with neoadjuvant chemotherapy and cystectomy is around 50%. There is no validated biomarker to guide the treatment decision. We investigated whether the Immunoscore (IS) could predict the pathologic response to neoadjuvant chemotherapy and survival outcomes. (2) Methods-This retrospective study evaluated the IS in 117 patients treated using neoadjuvant chemotherapy for localized MIBC from six centers (France and Greece). Pre-treatment tumor samples were immunostained for CD3+ and CD8+ T cells and quantified to determine the IS. The results were associated with the response to neoadjuvant chemotherapy, time to recurrence (TTR), and OS. (3) Results-Low (IS-0), intermediate (IS-1-2), and high (IS-3-4) ISs were observed in 36.5, 43.7, and 19.8% of the cohort, respectively. IS was positively associated with a pathologic complete response (pCR;

Indexed as

immuno-oncologyImmunoscoreneoadjuvant chemotherapypredictive response to chemotherapyprognostic scoreurothelial carcinoma

Identifiers

PMID33525361
PMCPMC7865364
OpenAlexW3126085039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.