ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2021
Global Brain Flexibility During Working Memory Is Reduced in a High-Genetic-Risk Group for Schizophrenia.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Linking Polygenic Risk of Schizophrenia to Variation in Magnetic Resonance Imaging Brain Measures: A Comprehensive Systematic Review.Schizophrenia bulletin · 2024Pooled it
- Trial
- Disrupted Coupling of Heart Rate-Dependent Brain Network Switching and Attentional Task Performance in Schizophrenia Spectrum Disorders.medRxiv : the preprint server for health sciences · 2026Article
- Dynamic frontoparietal flexibility and cognitive dysfunction in schizophrenia: disentangling the roles of symptom burden and childhood trauma.Psychological medicine · 2026Article
- Aberrant Modular Dynamics of Functional Networks in Schizophrenia and Their Relationship With Neurotransmitter and Gene Expression Profiles.Human brain mapping · 2025Article
- The dynamic reconfiguration of the functional network during episodic memory task predicts the memory performance.Scientific reports · 2024Article
- Assessing the Repeatability of Multi-Frequency Multi-Layer Brain Network Topologies Across Alternative Researcher's Choice Paths.Neuroinformatics · 2023Article
- Magical thinking in individuals with high polygenic risk for schizophrenia but no non-affective psychoses-a general population study.Molecular psychiatry · 2022Article
- From calcium imaging to graph topology.Network neuroscience (Cambridge, Mass.) · 2022Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundAltered functional brain connectivity has been proposed as an intermediate phenotype between genetic risk loci and clinical expression of schizophrenia. Genetic high-risk groups of healthy subjects are particularly suited for the investigation of this proposition because they can be tested in the absence of medication or other secondary effects of schizophrenia.
methodsHere, we applied dynamic functional connectivity analysis to functional magnetic resonance imaging data to reveal the reconfiguration of brain networks during a cognitive task. We recruited healthy carriers of common risk variants using the recall-by-genotype design. We assessed 197 individuals: 99 individuals (52 female, 47 male) with low polygenic risk scores (schizophrenia risk profile scores [SCZ-PRSs]) and 98 individuals (52 female, 46 male) with high SCZ-PRSs from both tails of the SCZ-PRS distribution from a genotyped population cohort, the Avon Longitudinal Study of Parents and Children (N = 8169). We compared groups both on conventional brain activation profiles, using the general linear model of the experiment, and on the neural flexibility index, which quantifies how frequent a brain region's community affiliation changes over experimental time.
resultsBehavioral performance and standard brain activation profiles did not differ significantly between groups. High SCZ-PRS was associated with reduced flexibility index and network modularity across n-back levels. The whole-brain flexibility index and that of the frontoparietal working memory network was associated with n-back performance. We identified a dynamic network phenotype related to high SCZ-PRS.
conclusionsSuch neurophysiological markers can become important for the elucidation of biological mechanisms of schizophrenia and, particularly, the associated cognitive deficit.
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