Evidence map›Paper›PMID 33524507›Full record

ArticleNeurotoxicology and teratology

A longitudinal study of the impact of marijuana on adult memory function: Prenatal, adolescent, and young adult exposures.

Jennifer A Willford, Lidush Goldschmidt, Natacha M De Genna, Nancy L Day, Gale A Richardson

Open access · greenAbstract read
In one paragraph

Article in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Ratings of executive function as a risk factor for adolescents' frequent cannabis use: A prospective longitudinal study.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2023
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. The Neurocognitive Effects of Cannabis Across the Lifespan.Current behavioral neuroscience reports · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jennifer A WillfordDepartment of Psychology, Slippery Rock University, Slippery Rock, PA, United States of America. Electronic address: Jennifer.Willford@sru.edu.
Lidush GoldschmidtUniversity of Pittsburgh Medical Center, Pittsburgh, PA, United States of America.
Natacha M De GennaUniversity of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, United States of America.
Nancy L DayUniversity of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, United States of America.
Gale A RichardsonUniversity of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, United States of America.
University of Pittsburgh · USSlippery Rock University · USUniversity of Pittsburgh Medical Center · US

Funding

PRENATAL MARIJUANA EXPOSURE: LONG-TERM OUTCOMESR01DA017786 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAY, NANCY LEE · 2005 to 2009
$2.4M
ALCOHOL USE DURING PREGNANCY: A LONGITUDINAL STUDYR01AA006666 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAY, NANCY L · 1985 to 2002
$544k
Effects of Prenatal Alcohol Exposure at 22 YearsR01AA018116 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAY, NANCY LEE · 2009 to 2010
$358k
NIAAA NIH HHS R01 AA006666NIAAA NIH HHS R01 AA018116NIDA NIH HHS R01 DA017786
6 · The paper itself

Abstract

More Americans are using marijuana than in previous decades but there are concerns over its long-term impact on cognitive functioning, especially memory. The literature on marijuana use and cognitive functioning is mixed, with some studies showing recovery of functioning upon abstinence from the drug and others showing long-term effects that persist. The latter seems especially true for individuals who initiate marijuana at a younger age and engage in more chronic patterns of use. The goal of the current study is to use prospectively collected data on young adults from a prenatal cohort to determine if there is an effect of early and/or current marijuana use on young adult memory, controlling for prenatal exposure to marijuana use, childhood memory deficits, and other significant covariates of memory functioning. At the 22-year follow-up phase of the Maternal Health Practices and Child Development (MHPCD) study, 524 young adults (58% Black, 42% White, 52% female) completed the Wechsler Memory Scale-III. Multiple regression analyses and structural equation modeling were used to determine the effect of marijuana exposure during gestation, early adolescence, and young adulthood on young adult memory function. Results indicated that initiating marijuana use before age 15 placed young adults at greater risk of memory deficits, even after controlling for childhood memory and current marijuana use. First trimester marijuana exposure also indirectly predicted young adult memory function via childhood memory deficits and early initiation of marijuana. These findings highlight the risk of prenatal marijuana exposure and early initiation of marijuana for long-term memory function in adulthood.

Indexed as

AdolescentAge of OnsetCohort StudiesFemaleHumansIntelligence TestsLearning DisabilitiesLongitudinal StudiesMaleMarijuana UseMemoryMemory DisordersNeuropsychological TestsPregnancyPrenatal Exposure Delayed EffectsWechsler ScalesAdolescentCannabisLearning and memoryMarijuanaNeuropsychologyPrenatal marijuanaYoung adult

Identifiers

PMID33524507
PMCPMC7965351
OpenAlexW3127911395

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.