Evidence map›Paper›PMID 33524393›Full record

ArticleThe Journal of biological chemistry

Angiotensin II increases activity of the ClC-K2 Cl

Naghmeh Hassanzadeh Khayyat, Oleg Zaika, Viktor N Tomilin, Kyrylo Pyrshev, Oleh Pochynyuk

Open access · goldAbstract read
In one paragraph

Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Intercalated Cell ClC-K2 Channel Contributes to Systemic ClFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  2. Angiotensin II acts through Rac1 to upregulate pendrin: role of NADPH oxidase.American journal of physiology. Renal physiology · 2024
    Article
  3. Article
  4. Biomolecules · 2023
    Review
  5. ClC-K2 ClFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Naghmeh Hassanzadeh KhayyatDepartment of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Oleg ZaikaDepartment of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Viktor N TomilinDepartment of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Kyrylo PyrshevDepartment of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Oleh PochynyukDepartment of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA. Electronic address: Oleh.M.Pochynyuk@uth.tmc.edu.
The University of Texas Health Science Center at Houston · USThe University of Texas Health Science Center · US

Funding

Physiology of ClC-K2/b Cl- channel in the collecting ductR01DK117865 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI POCHYNYUK, OLEH · 2019 to 2023
$1.7M
Regulation of K+ balance by distal nephron TRPV4 channelR01DK119170 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI POCHYNYUK, OLEH · 2018 to 2022
$1.7M
Aldosterone-independent regulation of ENaC by systemic saltR01DK095029 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI POCHYNYUK, OLEH · 2012 to 2016
$1.6M
NIDDK NIH HHS R01 DK095029NIDDK NIH HHS R01 DK117865NIDDK NIH HHS R01 DK119170
6 · The paper itself

Abstract

The renal collecting duct plays a critical role in setting urinary volume and composition, with principal cells transporting Na

Indexed as

Angiotensin IIAnimalsAnion Transport ProteinsChloride ChannelsKidney Tubules, CollectingMaleMiceMice, Inbred C57BLReactive Oxygen SpeciesAngiotensin IIAnion Transport ProteinsChloride ChannelsClcnkb protein, mouseReactive Oxygen Specieschloride transportG protein-coupled receptor (GPCR)hypertensionion channelNADPH oxidaserenal physiology

Identifiers

PMID33524393
PMCPMC7949157
OpenAlexW3126427021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.