ReviewJournal of obstetric, gynecologic, and neonatal nursing : JOGNN2021
Integrative Review of Early Life Adversity and Cortisol Regulation in Pregnancy.
Review in Journal of obstetric, gynecologic, and neonatal nursing : JOGNN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Bridging epigenetics and pharmacology through systematic reviews tailored to WBS methodology: the triangle decision-making model as a pioneering translational biological drug delivery system.Frontiers in medicine · 2025Pooled it
- Salivary cortisol reactivity to stress in pregnancy: A scoping review.Psychoneuroendocrinology · 2026Article
- Prenatal stress, intimate partner violence and maternal cortisol trajectories: insights from a prospective birth cohort from São Paulo, Brazil.Scientific reports · 2026Article
- Maternal adversity and peripheral proinflammatory cytokine concentrations in pregnancy.Brain, behavior, & immunity - health · 2026Article
- The role of perinatal perceived stress in the setting of adverse childhood experience and perinatal anxiety and depressive symptoms.BMC psychology · 2025Article
- Mother infant cortisol levels and maternal childhood adversity.Scientific reports · 2025Article
- Effects of Sociospatial Inequality on Exposure to Stress, Symptoms of Depression, and Cortisol Rhythms in Pregnancy.Journal of obstetric, gynecologic, and neonatal nursing : JOGNN · 2025Observational
- The effect of maternal childhood maltreatment on postpartum mother-child bonding and maternal hair glucocorticoids.European journal of psychotraumatology · 2024Article
- Implications of childhood adversity for women's perinatal sleep quality and depressive symptoms over time: A serial mediation model.Journal of sleep research · 2024Article
- Developmental cascades from maternal preconception stress to child behavior problems: Testing multilevel preconception, prenatal, and postnatal influences.Developmental psychology · 2024Article
- Postpartum symptoms of anxiety, depression and stress: differential relationships to women's cortisol profiles.Archives of women's mental health · 2024Article
- The effects of IPV and mental health symptoms on HPA axis functioning during early pregnancy.Archives of women's mental health · 2024Article
- Placental Cortisol Dysregulation in Mothers with Experiences of Childhood Adversity: Potential Mechanisms and Clinical Implications.Journal of clinical medicine · 2024Article
- Relationships Among Number of Stressors, Perceived Stress, and Salivary Cortisol Levels During the Third Trimester of Pregnancy.Journal of obstetric, gynecologic, and neonatal nursing : JOGNN · 2024Article
- [Research progress on the mechanism of the impact of maternal childhood trauma on intergenerational transmission].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Cortisol Regulation among Women Who Experience Suicidal Ideation during Pregnancy.Journal of affective disorders reports · 2023Article
- Stress before conception and during pregnancy and maternal cortisol during pregnancy: A scoping review.Psychoneuroendocrinology · 2023Article
- Childhood family stress modifies the association between perinatal stressful life events and depressive symptoms.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2023Article
- Association between trauma exposure and glucocorticosteroid concentration in hair during pregnancy.Psychoneuroendocrinology · 2023Article
- Maternal history of childhood maltreatment is associated with diurnal cortisol and DNA methylation of placental 11-beta-hydroxysteroid dehydrogenase type 2.Obstetric medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectiveTo synthesize published findings on the relationship between early life adversity and hypothalamic-pituitary-adrenal axis cortisol parameters in pregnant women. DATA SOURCES: We searched PubMed, CINAHL, and PsycINFO databases using variants and combinations of the keywords early life adversity, pregnancy, hypothalamic-pituitary-adrenal axis, and cortisol. STUDY SELECTION: We selected articles that included pregnant participants, included measures of cortisol and early life adversity, were published in English in a peer-reviewed journal, and were of sufficient methodologic quality. Date of publication was unrestricted through May 2020. DATA EXTRACTION: Twenty-five articles met the inclusion criteria and were evaluated for quality and risk of bias. Sources of cortisol included saliva, hair, plasma, and amniotic fluid. DATA SYNTHESIS: We categorized findings according to four physiologically distinct cortisol output parameters: diurnal (daily pattern), phasic (in response to an acute stressor), tonic (baseline level), and pregnancy-related change. Preliminary evidence suggests that early adversity may be associated with elevated cortisol awakening response (diurnal) and blunted response to acute stressors (phasic), irrespective of other psychosocial symptoms or current stress. For women with high levels of current stress or psychological symptoms, early adversity was associated with higher baseline (tonic) cortisol levels.
conclusionEarly life adversity in women is linked with alterations in cortisol regulation that are apparent during pregnancy. Researchers should examine how variations in each cortisol parameter differentially predict pregnancy health risk behaviors, maternal mental health, and neonatal health outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.