ArticleThe Journal of clinical endocrinology and metabolism2021
The Association of Lactation Duration with Visceral and Pericardial Fat Volumes in Parous Women: The CARDIA Study.
Article in The Journal of clinical endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Associations of breastfeeding with maternal and child health outcomes: umbrella review.The American journal of clinical nutrition · 2025Pooled it
- Cumulative breastfeeding duration and incidence of diabetes in the multiethnic cohort study.Global perspectives on nutrition · 2026Article
- Lactation duration and the risk of type 2 diabetes mellitus in parous women: A perspective on socioeconomic status disparity.Journal of advanced research · 2025Article
- Associations of ever breastfeeding with risk of all-cause and cardiovascular disease mortality among women with and without diabetes: a cohort study.International breastfeeding journal · 2025Article
- Comparison Between SGLT2 Inhibitors and Lactation: Implications for Cardiometabolic Health in Parous Women.Metabolic syndrome and related disorders · 2025Review
- Pregnancy Complications and Long-Term Atherosclerotic Cardiovascular Disease Risk.Current atherosclerosis reports · 2025Review
- Prospective associations between breast feeding, metabolic health, inflammation and bone density in women with prior gestational diabetes mellitus.BMJ open diabetes research & care · 2024Article
- Associations of Physical Activity and Lactation Duration With Cardiometabolic Risk Factors: The CARDIA Study.JACC. Advances · 2023Article
- Women's Reproductive Milestones and Cardiovascular Disease Risk: A Review of Reports and Opportunities From the CARDIA Study.Journal of the American Heart Association · 2023Review
- Article
- Adverse Pregnancy Outcomes: The Missing Link in Discovering the Role of Lactation in Cardiovascular Disease Prevention.Journal of the American Heart Association · 2022Article
- Prolactin and Maternal Metabolism in Women With a Recent GDM Pregnancy and Links to Future T2D: The SWIFT Study.The Journal of clinical endocrinology and metabolism · 2022Article
- Pregnancy and Reproductive Risk Factors for Cardiovascular Disease in Women.Circulation research · 2022Review
- Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications.Diabetes & metabolism journal · 2022Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundLactation is associated with lower risks for cardiovascular disease in women. Organ-related adiposity, which plays significant roles in the development of cardiometabolic diseases, could help explain this observation. We evaluated the association of lactation duration with visceral (VAT) and pericardial (PAT) fat volumes in women.
methodsData were obtained from 910 women enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) study (1985-1986) without diabetes prior to pregnancy who had ≥1 birth during 25 years of follow-up and had VAT and PAT measured from computed tomographic scans in 2010-2011. Cumulative lactation duration across all births since baseline was calculated from self-reports collected at periodic exams.
resultsAt baseline, the average age of women (48% black, 52% white) was 24 ± 3.7 years. After controlling for baseline age, race, smoking status, body mass index, fasting glucose, family history of diabetes, fat intake, total cholesterol, physical activity, and follow-up covariates (parity, gestational diabetes), the mean fat volumes across categories of lactation [none (n = 221), 1-5 months (n = 306), 6-11 months (n = 210), and ≥12 months (n = 173)] were 122.0, 113.7 105.0, and 110.1 cm3 for VAT and 52.2, 46.7, 44.5, and 43.4 cm3 for PAT, respectively. Changes in body weight from the first post-baseline birth to the end of follow-up mediated 21% and 18% of the associations of lactation with VAT and PAT, respectively.
conclusionsIn this prospective study, longer cumulative lactation duration was associated with lower VAT and PAT volumes, with weight gain partially mediating these associations.
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