ArticleThe Journal of clinical endocrinology and metabolism2021
Maternal Oxidative Stress Biomarkers in Pregnancy and Child Growth from Birth to Age 6.
Article in The Journal of clinical endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Maternal oxidative stress biomarkers across pregnancy in relation to fetal growth: evidence from the TIDES cohort.American journal of epidemiology · 2026Article
- Associations of glyphosate and aminomethylphosphonic acid (AMPA) concentrations with birth outcomes in pregnant women from the Midwestern U.S.International journal of hygiene and environmental health · 2026Article
- Oxidative stress and fetal weight: observational findings from a pregnancy cohort in New York City.Journal of perinatology : official journal of the California Perinatal Association · 2026Observational
- A prospective study of per- and polyfluoroalkyl substances (PFAS), stress, and birth size in a cohort of U.S. Black women.Environmental health : a global access science source · 2026Article
- Dynamic Lipid-Glycaemic Index and Inflammation-Endothelial Shifts and Fetal Aortic Wall Thickening: A Repeated-Measures Gestational Phenotyping Study.Medicina (Kaunas, Lithuania) · 2025Article
- Early menopause in mothers and the risks of pre-diabetes and type 2 diabetes mellitus in female and male offspring: a population-based cohort study.Reproductive biology and endocrinology : RB&E · 2025Article
- The Influence of Maternal Diet in Late Pregnancy on Malondialdehyde and Cortisol Levels in Maternal and Cord Blood.Nutrients · 2025Article
- Maternal Obesity Alters Placental and Umbilical Cord Plasma Oxidative Stress, a Cross-Sectional Study.International journal of molecular sciences · 2024Article
- Genetic predicted causal inferences between antioxidants and birth weight.Journal of clinical biochemistry and nutrition · 2024Article
- Maternal exposure to aircraft emitted ultrafine particles during pregnancy and likelihood of ASD in children.Environment international · 2023Article
- Prenatal oxidative stress and rapid infant weight gain.International journal of obesity (2005) · 2023Article
- Supporting early childhood routines to promote cardiovascular health across the life course.Current problems in pediatric and adolescent health care · 2023Article
- Associations between cord blood metabolic factors and early-childhood growth and overweight and obesity.Frontiers in endocrinology · 2023Article
- Maternal Dexamethasone Exposure Induces Sex-Specific Changes in Histomorphology and Redox Homeostasis of Rat Placenta.International journal of molecular sciences · 2022Article
- Associations of per- and polyfluoroalkyl substances (PFAS) and their mixture with oxidative stress biomarkers during pregnancy.Environment international · 2022Article
- The association between prenatal FFree radical biology & medicine · 2022Article
- Associations between social, biologic, and behavioral factors and biomarkers of oxidative stress during pregnancy: Findings from four ECHO cohorts.The Science of the total environment · 2022Article
- Markers of Oxidative Stress in Obstetrics and Gynaecology-A Systematic Literature Review.Antioxidants (Basel, Switzerland) · 2022Review
- Oxidative Balance Score during Pregnancy Is Associated with Oxidative Stress in the CANDLE Study.Nutrients · 2022Article
- Prenatal Phthalate Exposure and Child Weight and Adiposity fromEnvironmental health perspectives · 2022Article
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 1 country.
Funding
Abstract
contextMaternal oxidative stress in pregnancy can arise through a multitude of sources and may have lifelong consequences for the child. Animal studies suggest that prenatal oxidative stress may contribute to metabolic dysfunction and excessive weight gain in the offspring. However, this relationship has been studied minimally in humans.
objectiveDetermine the association between prenatal oxidative stress biomarkers and child weight and body mass index (BMI) z-scores from birth to age 6.
methodsWithin The Infant Development and the Environment Study (TIDES) prospective pregnancy cohort, we calculated age- and sex-specific Z-scores for child weight and BMI, measured between birth and age 6 (N = 736). Three oxidative stress biomarkers were quantified in third-trimester urine, including 8-iso-prostaglandin F2α (8-iso-PGF2α), its primary metabolite, and prostaglandin F2α (PGF2α). We examined associations between each biomarker and Z-scores using linear regression as well as group-based trajectory modeling.
resultsPrenatal 8-iso-PGF2α and its metabolite were associated with lower birth weight and higher weight at age 4. For example, an ln-unit increase in 8-iso-PGF2α was associated with 0.17 SD higher weight at age 4 (95% CI 0.01, 0.33). These biomarkers were also associated with higher BMI at age 4. Finally, within 4 unique weight trajectories (low, normal, high, and low-high), children of mothers with higher 8-iso-PGF2α were 2.56 times more likely (95% CI 1.22, 5.41) to be in the low-high trajectory than children in the normal group.
conclusionWe observed associations between third-trimester oxidative stress and lower birth weight as well as higher early childhood weight and BMI. These findings have important implications for understanding the developmental origins of childhood weight gain and metabolic disease.
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