ArticleThe Journal of clinical endocrinology and metabolism2021
Postconvalescent SARS-CoV-2 IgG and Neutralizing Antibodies are Elevated in Individuals with Poor Metabolic Health.
Article in The Journal of clinical endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Adherence to the Mediterranean diet, particularly olive oil intake, and metabolic health parameters are independently associated with SARS-CoV-2 vaccine-induced IgG responses.Metabolism open · 2026Article
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- Association of Obesity with SARS-CoV-2 and Its Relationship with the Humoral Response Prior to Vaccination in the State of Mexico: A Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2023Article
- Seroprevalence of IgG and Subclasses against the Nucleocapsid of SARS-CoV-2 in Health Workers.Viruses · 2023Article
- COVID, the Gut, and Nutritional Implications.Current surgery reports · 2023Review
- Longitudinal anti-SARS-CoV-2 antibody immune response in acute and convalescent patients.Frontiers in cellular and infection microbiology · 2023Article
- Nutritional management of individuals with obesity and COVID-19: ESPEN expert statements and practical guidance.Clinical nutrition (Edinburgh, Scotland) · 2022Article
- COVID-19: Lessons on malnutrition, nutritional care and public health from the ESPEN-WHO Europe call for papers.Clinical nutrition (Edinburgh, Scotland) · 2022Article
- COVID-19, obesity, and immune response 2 years after the pandemic: A timeline of scientific advances.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Review
- Host Predictors of Broadly Cross-Reactive Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants of Concern Differ Between Infection and Vaccination.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Observational
- Time dependent decline of neutralizing antibody titers in COVID-19 patients from Pune, India and evidence of reinfection.Microbes and infection · 2022Article
- Article
- SARS-CoV-2 Antibody Response Is Associated with Age and Body Mass Index in Convalescent Outpatients.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Robust antibody response in children to acute COVID-19 infection and lasts for months.The Journal of pediatrics · 2022Article
- Long-term effects of obesity on COVID-19 patients discharged from hospital.Immunity, inflammation and disease · 2021Article
- Infection induced SARS-CoV-2 seroprevalence and heterogeneity of antibody responses in a general population cohort study in Catalonia Spain.Scientific reports · 2021Article
- Naturally Acquired SARS-CoV-2 Immunity Persists for Up to 11 Months Following Infection.The Journal of infectious diseases · 2021Observational
- Serological and viral genetic features of patients with COVID-19 in a selected German patient cohort-correlation with disease characteristics.GeroScience · 2021Article
- Association of Age With SARS-CoV-2 Antibody Response.JAMA network open · 2021Article
Corrections and comments
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Authors and funding
19 authors at 2 institutions in 1 country.
Funding
Abstract
purposeComorbidities making up metabolic syndrome (MetS), such as obesity, type 2 diabetes, and chronic cardiovascular disease can lead to increased risk of coronavirus disease-2019 (COVID-19) with a higher morbidity and mortality. SARS-CoV-2 antibodies are higher in severely or critically ill COVID-19 patients, but studies have not focused on levels in convalescent patients with MetS, which this study aimed to assess.
methodsThis retrospective study focused on adult convalescent outpatients with SARS-CoV-2 positive serology during the COVID-19 pandemic at NewYork Presbyterian/Weill Cornell. Data collected for descriptive and correlative analysis included SARS-COV-2 immunoglobin G (IgG) levels and history of MetS comorbidities from April 17, 2020 to May 20, 2020. Additional data, including SARS-CoV-2 IgG levels, body mass index (BMI), hemoglobin A1c (HbA1c) and lipid levels were collected and analyzed for a second cohort from May 21, 2020 to June 21, 2020. SARS-CoV-2 neutralizing antibodies were measured in a subset of the study cohort.
resultsSARS-CoV-2 IgG levels were significantly higher in convalescent individuals with MetS comorbidities. When adjusted for age, sex, race, and time duration from symptom onset to testing, increased SARS-CoV-2 IgG levels remained significantly associated with obesity (P < 0.0001). SARS-CoV-2 IgG levels were significantly higher in patients with HbA1c ≥6.5% compared to those with HbA1c <5.7% (P = 0.0197) and remained significant on multivariable analysis (P = 0.0104). A positive correlation was noted between BMI and antibody levels [95% confidence interval: 0.37 (0.20-0.52) P < 0.0001]. Neutralizing antibody titers were higher in COVID-19 individuals with BMI ≥ 30 (P = 0.0055).
conclusionPostconvalescent SARS-CoV-2 IgG and neutralizing antibodies are elevated in obese patients, and a positive correlation exists between BMI and antibody levels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.