ArticlePloS one2021
Association between metabolically healthy obesity/overweight and cardiovascular disease risk: A representative cohort study in Taiwan.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 52 citations in OpenAlex.
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- 2024 Guidelines of the Taiwan Society of Cardiology on the Primary Prevention of Atherosclerotic Cardiovascular Disease --- Part I.Acta Cardiologica Sinica · 2024Article
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- Sulfur dioxide-free wine with polyphenols promotes lipid metabolism via the Nrf2 pathway and gut microbiota modulation.Food chemistry: X · 2024Article
- Obesity and metabolic state are associated with increased healthcare resource and medication use and costs: a Finnish population-based study.The European journal of health economics : HEPAC : health economics in prevention and care · 2023Article
- Cardiovascular Disease Burden Attributable to High Body Mass Index in Taiwan.Acta Cardiologica Sinica · 2023Article
- Association of body mass index, metabolic health status and clinical outcomes in acute myocardial infarction patients: a national registry-based study.Frontiers in cardiovascular medicine · 2023Article
- Association betweenJournal of nutritional science · 2023Article
- Overweight and Obesity as Risk Factors for Recurrent Herpetic Stromal Keratitis during Long-Term Antiviral Prophylaxis.Viruses · 2022Article
- Validity of Body Image Pictogram to Determine Overweight/Obesity in Adults from Less Developed Populations: Results From Pars Cohort Study.Archives of Iranian medicine · 2022Article
- Effects of cognitive ageing trajectories on multiple adverse outcomes among Chinese community-dwelling elderly population.BMC geriatrics · 2022Article
- Clinical Impact of Semaglutide, a Glucagon-Like Peptide-1 Receptor Agonist, on Obesity Management: A Review.Clinical pharmacology : advances and applications · 2022Review
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- Do Metabolically Healthy People with Obesity Have a Lower Health-Related Quality of Life? A Prospective Cohort Study in Taiwan.Journal of clinical medicine · 2021Article
- Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the relationship between metabolically healthy obesity and cardiovascular disease risk in Taiwanese individuals.
methodsTaiwanese individuals were recruited from a nationwide, representative community-based prospective cohort study and classified according to body mass index as follows: normal weight (18.5-23.9 kilogram (kg)/meter(m)2) and obesity/overweight (≥24 kg/m2). Participants without diabetes, hypertension, and hyperlipidemia and who did not meet the metabolic syndrome without waist circumference criteria were considered metabolically healthy. The study end points were cardiovascular disease morbidity and mortality. Multivariable adjusted hazard ratios and 95% confidence intervals were obtained from a Cox regression analysis.
resultsAmong 5 358 subjects (mean [standard deviation] age, 44.5 [15.3] years; women, 48.2%), 1 479 were metabolically healthy with normal weight and 491 were metabolically healthy with obesity. The prevalence of metabolically healthy obesity/overweight was 8.6% in the Taiwanese general population, which included individuals who were >20 years old, not pregnant, and did not have CVD (n = 5,719). In the median follow-up period of 13.7 years, 439 cardiovascular disease events occurred overall and 24 in the metabolically healthy obesity group. Compared with the reference group, the metabolically healthy obesity group had a significantly higher cardiovascular disease risk (adjusted hazard ratio: 1.74, 95% confidence interval: 1.02, 2.99).
conclusionsIndividuals with metabolically healthy obesity have a higher risk of cardiovascular disease and require aggressive body weight control for cardiovascular disease control.
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