ArticlePLoS genetics2021
Increased dopaminergic neurotransmission results in ethanol dependent sedative behaviors in Caenorhabditis elegans.
Article in PLoS genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- AlteredeNeuro · 2026Article
- FLP-15 functions through the GPCR NPR-3 to regulate local and global search behaviours in Caenorhabditis elegans.Communications biology · 2026Article
- Article
- AlteredbioRxiv : the preprint server for biology · 2025Article
- The dopaminergic system ofRoyal Society open science · 2025Review
- FLP-15 modulates the amplitude of body-bends during locomotion inOpen biology · 2025Article
- Ethanol alters mechanosensory habituation in C. elegans by way of the BK potassium channel through a novel mechanism.PloS one · 2025Article
- Role of dopamine in responsiveness to acute ethanol exposure inmicroPublication biology · 2025Article
- From Natural Behavior to Drug Screening: Invertebrates as Models to Study Mechanisms Associated with Alcohol Use Disorders.Current topics in behavioral neurosciences · 2025Review
- nlr-1/CNTNAP regulates dopamine circuit structure and foraging behaviors in C. elegans.Communications biology · 2024Article
- Evidence for involvement of the alcohol consumption WDPCP gene in lipid metabolism, and liver cirrhosis.Scientific reports · 2023Article
- Single-nucleus resolution mapping of the adult C. elegans and its application to elucidate inter- and trans-generational response to alcohol.Cell reports · 2023Article
- Regulation and modulation of biogenic amine neurotransmission inFrontiers in physiology · 2023Review
- The dopamine membrane transporter plays an active modulatory role in synaptic dopamine homeostasis.Journal of neuroscience research · 2022Article
- Corazonin Neurons Contribute to Dimorphic Ethanol Sedation Sensitivity inFrontiers in neural circuits · 2022Article
- Ethanol-induced Sedative Behavior: An Assay to Investigate Increased Dopamine Signaling inBio-protocol · 2021Article
- Transcriptional analysis of the response of C. elegans to ethanol exposure.Scientific reports · 2021Article
- Neuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs.Frontiers in molecular neuroscience · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Ethanol is a widely used drug, excessive consumption of which could lead to medical conditions with diverse symptoms. Ethanol abuse causes dysfunction of memory, attention, speech and locomotion across species. Dopamine signaling plays an essential role in ethanol dependent behaviors in animals ranging from C. elegans to humans. We devised an ethanol dependent assay in which mutants in the dopamine autoreceptor, dop-2, displayed a unique sedative locomotory behavior causing the animals to move in circles while dragging the posterior half of their body. Here, we identify the posterior dopaminergic sensory neuron as being essential to modulate this behavior. We further demonstrate that in dop-2 mutants, ethanol exposure increases dopamine secretion and functions in a DVA interneuron dependent manner. DVA releases the neuropeptide NLP-12 that is known to function through cholinergic motor neurons and affect movement. Thus, DOP-2 modulates dopamine levels at the synapse and regulates alcohol induced movement through NLP-12.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.