ArticleScience advances2021
Gut microbiota from patients with arteriosclerotic CSVD induces higher IL-17A production in neutrophils via activating RORγt.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Circulating immune cells in cerebral small vessel disease: a systematic review.Biogerontology · 2025Pooled it
- Biomarker advancements in cerebral small vessel disease: An overview.Neural regeneration research · 2026Article
- The role of inflammation in cerebral small vessel disease and vascular cognitive impairment, and therapeutic implications.International journal of stroke : official journal of the International Stroke Society · 2026Review
- Gut Lachnospiraceae improves white matter injury-related cognitive decline by increasing L-arginine.Cellular & molecular biology letters · 2026Article
- Resolving cognitive heterogeneity in white matter hyperintensities through integrated analyses of microbiome, metabolome, and brain glymphatic function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Neuroinflammation and blood-brain barrier dysfunction in cerebral small vessel disease: mechanisms, biomarkers, and therapeutic implications.European journal of medical research · 2026Review
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- Association between gut microbiota and imaging biomarkers in arteriosclerotic cerebral small vessel disease with idiopathic normal pressure hydrocephalus.Frontiers in neuroscience · 2026Article
- Causal effect of gut microbiota and its metabolites on cerebral small vessel disease: A multivariable Mendelian randomization analysis.Medicine · 2025Article
- Neuroimmunology in ageing and longevity: a special collection issue of Biogerontology.Biogerontology · 2025Article
- Elevated phenylacetylglutamine caused by gut dysbiosis associated with type 2 diabetes increases neutrophil extracellular traps formation and exacerbates brain infarction.Clinical science (London, England : 1979) · 2025Article
- Matrix Dynamics and Microbiome Crosstalk: Matrix Metalloproteinases as Key Players in Disease and Therapy.International journal of molecular sciences · 2025Review
- Review of the mechanism of infection induced cerebral small vessel disease.Frontiers in immunology · 2025Review
- Myelin endocytosis by brain endothelial cells causes endothelial iron overload and oligodendroglial iron hunger in hypoperfusion-induced white matter injury.CNS neuroscience & therapeutics · 2024Article
- Deep learning based on susceptibility-weighted MR sequence for detecting cerebral microbleeds and classifying cerebral small vessel disease.Biomedical engineering online · 2023Article
- Alteration and clinical potential in gut microbiota in patients with cerebral small vessel disease.Frontiers in cellular and infection microbiology · 2023Article
- Shen-Ling-Bai-Zhu-San Enhances the Antipneumonia Effect of Cefixime in Children by Ameliorating Gut Microflora, Inflammation, and Immune Response.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Influence of the gut microbiome on inflammatory and immune response after stroke.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
- Gut-Derived Metabolite Phenylacetylglutamine and White Matter Hyperintensities in Patients With Acute Ischemic Stroke.Frontiers in aging neuroscience · 2021Article
- Impact of cerebral small vessel disease burden and systemic clinical phenotypes on short-term neurological outcomes after acute ischemic stroke.Frontiers in neurologyArticle
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Authors and funding
37 authors at 2 institutions in 1 country.
Wei CaiDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.ORCID 0000-0003-4059-4627
Xiaodong ChenDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.ORCID 0000-0002-9094-4691
Xuejiao MenDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Hengfang RuanDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.ORCID 0000-0002-7690-9400
Mengyan HuDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Sanxin LiuDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Tingting LuDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Jinchi LiaoDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.ORCID 0000-0002-2327-769X
Bingjun ZhangDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Danli LuDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Yinong HuangDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Ping FanDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.ORCID 0000-0003-0807-9182
Junping RaoDepartment of Neurology, Yuedong Hospital, the Third Affiliated Hospital of Sun Yat-sen University, Meizhou, Guangdong 514011, China.
Chunyan LeiSouth China Institute of Biomedicine, Guangzhou, Guangdong 510535, China.
Jihui WangDepartment of Psychiatry, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China.
Xiaomeng MaDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.ORCID 0000-0001-9864-1647
Qiang ZhuDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Lili LiDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.ORCID 0000-0003-0552-7250
Xiuyun ZhuDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.ORCID 0000-0002-9367-6485
Yujiao HouDepartment of Neurology, Yuedong Hospital, the Third Affiliated Hospital of Sun Yat-sen University, Meizhou, Guangdong 514011, China.
Shu LiDepartment of Neurology, Yuedong Hospital, the Third Affiliated Hospital of Sun Yat-sen University, Meizhou, Guangdong 514011, China.
Qing DongDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.ORCID 0000-0002-2400-5477
Qing TianDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Lulu AiDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Wenjing LuoDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Mengyun ZuoDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Liping ShenDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Congyan XieDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Hongzhong SongDepartment of Neurology, Yuedong Hospital, the Third Affiliated Hospital of Sun Yat-sen University, Meizhou, Guangdong 514011, China.
Ganlin XuSouth China Institute of Biomedicine, Guangzhou, Guangdong 510535, China.
Kangdi ZhengSouth China Institute of Biomedicine, Guangzhou, Guangdong 510535, China.ORCID 0000-0002-3652-7424
Zhao ZhangSouth China Institute of Biomedicine, Guangzhou, Guangdong 510535, China.
Yongjun LuRun Ze Laboratory for Gastrointestinal Microbiome Study, School of Life Sciences and Biomedical Center of Sun Yat-sen University, Guangzhou, Guangdong 510275, China.
Wei QiuDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Tao ChenSouth China Institute of Biomedicine, Guangzhou, Guangdong 510535, China.ORCID 0000-0002-8261-8802
Andy Peng XiangDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China. lzq1828@outlook.com xiangp@mail.sysu.edu.cn.ORCID 0000-0003-3409-5012
Zhengqi LuDepartment of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China. lzq1828@outlook.com xiangp@mail.sysu.edu.cn.ORCID 0000-0002-2118-0368
Sun Yat-sen University · CNGuangzhou Institutes of Biomedicine and Health · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intestinal microbiota shape the host immune system and influence the outcomes of various neurological disorders. Arteriosclerotic cerebral small vessel disease (aCSVD) is highly prevalent among the elderly with its pathological mechanisms yet is incompletely understood. The current study investigated the ecology of gut microbiota in patients with aCSVD, particularly its impact on the host immune system. We reported that the altered composition of gut microbiota was associated with undesirable disease outcomes and exacerbated inflammaging status. When exposed to the fecal bacterial extracts from a patient with aCSVD, human and mouse neutrophils were activated, and capacity of interleukin-17A (IL-17A) production was increased. Mechanistically, RORγt signaling in neutrophils was activated by aCSVD-associated gut bacterial extracts to up-regulate IL-17A production. Our findings revealed a previously unrecognized implication of the gut-immune-brain axis in aCSVD pathophysiology, with therapeutic implications.
Indexed as
Gastrointestinal MicrobiomeAgedAnimalsHumansInterleukin-17MiceNeutrophilsNuclear Receptor Subfamily 1, Group F, Member 3Plant ExtractsInterleukin-17Nuclear Receptor Subfamily 1, Group F, Member 3Plant Extracts
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