Evidence map›Paper›PMID 33523928›Full record

ArticleScience advances2021

Axodendritic versus axosomatic cochlear efferent termination is determined by afferent type in a hierarchical logic of circuit formation.

Jemma L Webber, John C Clancy, Yingjie Zhou, Natalia Yraola, Kazuaki Homma, Jaime García-Añoveros

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  8. Deletion ofFrontiers in cellular neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jemma L WebberDepartment of Anesthesiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-9163-9309
John C ClancyDepartment of Anesthesiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0003-2867-9740
Yingjie ZhouDepartment of Anesthesiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Natalia YraolaDepartment of Anesthesiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Kazuaki HommaDepartment of Otolaryngology-Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-4440-2277
Jaime García-AñoverosDepartment of Anesthesiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. anoveros@northwestern.edu.ORCID 0000-0001-6561-9048
Northwestern University · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9M
Outer and Inner Hair Cell DevelopmentR01DC015903 · NIDCD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Jaime Garcia-Anoveros · 2017 to 2026
$5.8M
Defining the pathological mechanisms of hereditary hearing lossR01DC017482 · NIDCD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HOMMA, KAZUAKI · 2019 to 2023
$1.7M
Development of Afferent and Efferent Innervation in the Inner EarK01DC018852 · NIDCD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WEBBER, JEMMA LOUISE · 2020 to 2024
$579k
Andor Revolution XD Live Cell Imaging System with Photomanipulation LaserS10RR031680 · NCRR · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GELFAND, VLADIMIR I · 2011 to 2011
$437k
NCI NIH HHS P30 CA060553NCRR NIH HHS S10 RR031680NIDCD NIH HHS K01 DC018852NIDCD NIH HHS R01 DC015903NIDCD NIH HHS R01 DC017482
6 · The paper itself

Abstract

Hearing involves a stereotyped neural network communicating cochlea and brain. How this sensorineural circuit assembles is largely unknown. The cochlea houses two types of mechanosensory hair cells differing in function (sound transmission versus amplification) and location (inner versus outer compartments). Inner (IHCs) and outer hair cells (OHCs) are each innervated by a distinct pair of afferent and efferent neurons: IHCs are contacted by type I afferents receiving axodendritic efferent contacts; OHCs are contacted by type II afferents and axosomatically terminating efferents. Using an

Identifiers

PMID33523928
PMCPMC7817091
OpenAlexW3123333604

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.