Evidence map›Paper›PMID 33523916›Full record

ArticleScience advances2021

A deep sleep stage in

Bart van Alphen, Evan R Semenza, Melvyn Yap, Bruno van Swinderen, Ravi Allada

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed.

  1. Invertebrate brains as diversified models for understanding sleep mechanisms and function.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
    Review
  2. Article
  3. A day sleep promoting role of phototransduction inNeurobiology of sleep and circadian rhythms · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Inferring the genetic basis of sleep states inbioRxiv : the preprint server for biology · 2026
    Article
  8. Current Evidence for Sleep States inCurrent sleep medicine reports · 2026
    Review
  9. Article
  10. The use ofFrontiers in cell and developmental biology · 2026
    Review
  11. Early life sleep is associated with longevity inbioRxiv : the preprint server for biology · 2025
    Article
  12. 25 years ofFly · 2025
    Review
  13. Recognition of distinct sleep states inbioRxiv : the preprint server for biology · 2025
    Article
  14. The exploration of consciousness in insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bart van AlphenThe Department of Neurobiology, Northwestern University, 2205 Tech Drive, Hogan 2-160, Evanston, Illinois 60208, USA. bart.alphen@northwestern.edu r-allada@northwestern.edu.ORCID 0000-0001-8779-9940
Evan R SemenzaThe Department of Neurobiology, Northwestern University, 2205 Tech Drive, Hogan 2-160, Evanston, Illinois 60208, USA.ORCID 0000-0003-3494-6542
Melvyn YapThe Queensland Brain Institute, QBI Building, 79, The University of Queensland, St. Lucia QLD 4072, Australia.ORCID 0000-0003-2276-2877
Bruno van SwinderenThe Queensland Brain Institute, QBI Building, 79, The University of Queensland, St. Lucia QLD 4072, Australia.ORCID 0000-0001-6552-7418
Ravi AlladaThe Department of Neurobiology, Northwestern University, 2205 Tech Drive, Hogan 2-160, Evanston, Illinois 60208, USA. bart.alphen@northwestern.edu r-allada@northwestern.edu.ORCID 0000-0003-4371-1577

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sleep is a highly conserved state, suggesting that sleep's benefits outweigh the increased vulnerability it brings. Yet, little is known about how sleep fulfills its functions. Here, we used video tracking in tethered flies to identify a discrete deep sleep stage in

Identifiers

PMID33523916
PMCPMC7817094

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.