Evidence map›Paper›PMID 33523889›Full record

ArticleScience advances2021

Cell cycle inertia underlies a bifurcation in cell fates after DNA damage.

Jenny F Nathans, James A Cornwell, Marwa M Afifi, Debasish Paul, Steven D Cappell

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Immune Aging in Rheumatoid Arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. A concise guide to fluorescent cell cycle reporters for live-cell imaging.Frontiers in cell and developmental biology · 2025
    Review
  9. Article
  10. Article
  11. Transient ZnProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Article
  13. CDKN1A/p21 in Breast Cancer: Part of the Problem, or Part of the Solution?International journal of molecular sciences · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jenny F NathansLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-0276-734X
James A CornwellLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-5597-2339
Marwa M AfifiLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-4877-7447
Debasish PaulLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Steven D CappellLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. steven.cappell@nih.gov.ORCID 0000-0002-2885-7327

Funding

Control of cell cycle commitment by APCC-Cdh1ZIABC011830 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CAPPELL, STEVEN · 2018 to 2025
$4.7M
Intramural NIH HHS ZIA BC011830
6 · The paper itself

Abstract

The G

Indexed as

DNA DamageCell CycleCell DivisionCyclin-Dependent Kinase Inhibitor p21S PhaseCyclin-Dependent Kinase Inhibitor p21

Identifiers

PMID33523889
PMCPMC7806216

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.