ArticleScience advances2021
Recessive
Open access · goldAbstract read
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Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Kidney organoids as models for hereditary kidney diseases: Toward precision medicine (Review).Experimental and therapeutic medicine · 2026Review
- Advances and continuing challenges in differentiation of stem cells to human kidney tissue.Nature reviews. Nephrology · 2026Review
- Emerging genetic mechanisms of glomerular proteinuria: a podocyte-centered multi-layer network perspective.Frontiers in genetics · 2026Review
- Recessive variants in the intergenic NOS1AP-C1orf226 locus cause monogenic kidney disease responsive to anti-proteinuric treatment.Nature communications · 2025Article
- Review
- Dizocilpine Does Not AlterInternational journal of molecular sciences · 2025Article
- Mechanisms of podocyte injury in genetic kidney disease.Pediatric nephrology (Berlin, Germany) · 2025Review
- Enhancing diagnostic outcomes in kidney genetic disorders: the KidGen national kidney genomics study protocol.BMC nephrology · 2025Article
- Advancements in theFrontiers in toxicology · 2025Review
- KANK1 promotes breast cancer development by compromising Scribble-mediated Hippo activation.Nature communications · 2024Article
- Review
- A Natural Small Molecule Mitigates Kidney Fibrosis by Targeting Cdc42-mediated GSK-3β/β-catenin Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Advances and potential of regenerative medicine in pediatric nephrology.Pediatric nephrology (Berlin, Germany) · 2024Review
- Organoids are not organs: Sources of variation and misinformation in organoid biology.Stem cell reports · 2023Review
- Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation.Cell stem cell · 2023Review
- Placental DNA methylation profile as predicting marker for autism spectrum disorder (ASD).Molecular medicine (Cambridge, Mass.) · 2023Review
- Transplanted organoids empower human preclinical assessment of drug candidate for the clinic.Science advances · 2022Article
- Generation of Monogenic Candidate Genes for Human Nephrotic Syndrome Using 3 Independent Approaches.Kidney international reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors at 11 institutions in 5 countries.
Amar J MajmundarDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-9891-178X
Florian BuergerDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2655-387X
Thomas A ForbesKidney Development, Disease and Regeneration Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia.ORCID 0000-0001-6635-8855
Verena KlämbtDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Ronen SchneiderDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3845-3489
Konstantin DeutschDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2952-5030
Thomas M KitzlerDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Sara E HowdenKidney Development, Disease and Regeneration Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Michelle ScurrKidney Development, Disease and Regeneration Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Ker Sin TanKidney Development, Disease and Regeneration Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Mickaël KrzeminskiMolecular Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.
Eugen WidmeierDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-7773-5190
Daniela A BraunDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Ethan LaiDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Ihsan UllahDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7846-3118
Ali AmarDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3240-0741
Amy KolbDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2582-3391
Kaitlyn EddyDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Chin Heng ChenDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Daanya SalmanullahDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-4219-6833
Rufeng DaiDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Makiko NakayamaDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Isabel OttlewskiDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Caroline M KolvenbachDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2789-2654
Ana C Onuchic-WhitfordDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0362-0400
Youying MaoDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Nina MannDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Marwa M NabhanDepartment of Pediatrics, Center for Pediatric Nephrology and Transplantation, Kasr Al Ainy Medical School, Cairo University, Cairo, Egypt.
Seymour RosenDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Julie D Forman-KayMolecular Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0001-8265-972X
Neveen A SolimanDepartment of Pediatrics, Center for Pediatric Nephrology and Transplantation, Kasr Al Ainy Medical School, Cairo University, Cairo, Egypt.ORCID 0000-0002-8942-1973
Andreas HeilosDepartment of Pediatrics, Medical University of Vienna, Vienna, Austria.
Renate KainDepartment of Pathology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-2428-543X
Christoph AufrichtDepartment of Pediatrics, Medical University of Vienna, Vienna, Austria.
Shrikant ManeDepartment of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-3267-5139
Richard P LiftonDepartment of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA.
Shirlee ShrilDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-4218-7566
Melissa H LittleKidney Development, Disease and Regeneration Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia.ORCID 0000-0003-0380-2263
Friedhelm HildebrandtDepartment of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. friedhelm.hildebrandt@childrens.harvard.edu.ORCID 0000-0002-7130-0030
Boston Children's Hospital · USMedical University of Vienna · ATCairo University · EGMurdoch Children's Research Institute · AUThe University of Melbourne · AUYale University · USBeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · USHospital for Sick Children · CARoyal Children's Hospital · AUUniversity of Toronto · CA
Funding
Renal Physiology and Phenotyping CoreP30DK079310 · NIDDK · YALE UNIVERSITY · PI SOMLO, STEFAN · 2008 to 2022
$16.8MYale Center for Mendelian GenomicsUM1HG006504 · NHGRI · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER, GUNEL, MURAT · 2016 to 2020
$14.8MTRAINING PROGRAM IN ACADEMIC NEPHROLOGYT32DK007527 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 1986 to 2021
$8.8MThe Child Heath Research CenterK12HD052896 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Wendy K Chung · 2007 to 2026
$7.9MRESEARCH TRAINING IN PEDIATRIC NEPHROLOGYT32DK007726 · NIDDK · CHILDREN'S HOSPITAL BOSTON · PI BRISCOE, DAVID M. · 1994 to 2023
$5.9MIdentification and function of new genes causing childhood nephrotic syndromeR01DK076683 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HILDEBRANDT, FRIEDHELM · 2007 to 2021
$5.3MNHGRI Genome Sequencing Program Coordinating CenterU24HG008956 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI BUYSKE, STEVEN G, MATISE, TARA C. · 2016 to 2020
$4.9MMutations in TBC1D8B as a potential new cause of nephrotic syndromeF32DK122766 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI ONUCHIC-WHITFORD, ANA CLAUDIA · 2019 to 2020
$148kNHGRI NIH HHS U24 HG008956NHGRI NIH HHS UM1 HG006504NICHD NIH HHS K12 HD052896NIDDK NIH HHS F32 DK122766NIDDK NIH HHS P30 DK079310NIDDK NIH HHS R01 DK076683NIDDK NIH HHS T32 DK007527NIDDK NIH HHS T32 DK007726
Abstract
Nephrotic syndrome (NS) is a leading cause of chronic kidney disease. We found recessive
Indexed as
Adaptor Proteins, Signal TransducingKidney DiseasesNephrotic SyndromePodocytesActinsAnimalsForminsHumansMiceActinsAdaptor Proteins, Signal TransducingForminsNOS1AP protein, humanNos1ap protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.