ArticleScience advances2021
Ultradeep sequencing differentiates patterns of skin clonal mutations associated with sun-exposure status and skin cancer burden.
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Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
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Who cites it
33 citing papers in PubMed, 51 citations in OpenAlex.
- Reflectance confocal microscopy detects distinct features of field damage in chronically UV-irradiated SKH1 mouse skin.JID innovations : skin science from molecules to population health · 2026Article
- An estrogen receptor/E2F1/CDKN3 axis protects from UV-induced skin cancers in females.EMBO reports · 2026Article
- Article
- The dynamics of mutational selection in cutaneous squamous carcinogenesis.Communications biology · 2026Article
- Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma.Nature communications · 2025Article
- Mutational landscape of triple-negative breast cancer in African American women.Nature genetics · 2025Article
- High-Throughput Metabolomic Profiling of Skin Lesions: Comparative Study of Cutaneous Squamous Cell Carcinoma, Basal Cell Carcinoma, and Normal Skin Via e-Biopsy Sampling.Cellular and molecular bioengineering · 2025Article
- Commensal papillomavirus immunity preserves the homeostasis of highly mutated normal skin.Cancer cell · 2025Article
- Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma.bioRxiv : the preprint server for biology · 2024Article
- Photodynamic therapy reduces the burden of small ultraviolet-induced epidermal clones in human and mouse skin.The British journal of dermatology · 2024Article
- The Mutational and Microenvironmental Landscape of Cutaneous Squamous Cell Carcinoma: A Review.Cancers · 2024Review
- Mutational Landscapes of Normal Skin and Their Potential Implications in the Development of Skin Cancer: A Comprehensive Narrative Review.Journal of clinical medicine · 2024Review
- High-throughput lipidomic profiles sampled with electroporation-based biopsy differentiate healthy skin, cutaneous squamous cell carcinoma, and basal cell carcinoma.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- ArCH: improving the performance of clonal hematopoiesis variant calling and interpretation.Bioinformatics (Oxford, England) · 2024Article
- Assessment of RAS-RAF-MAPK Pathway Mutation Status in Healthy Skin, Benign Nevi, and Cutaneous Melanomas: Pilot Study Using Droplet Digital PCR.International journal of molecular sciences · 2024Article
- Postoperative Radiation Therapy Is Indicated for "Low-Risk" Pathologic Stage I Merkel Cell Carcinoma of the Head and Neck Region but Not for Other Locations.Advances in radiation oncology · 2024Article
- ORAOV1, CCND1, and MIR548K Are the Driver Oncogenes of the 11q13 Amplicon in Squamous Cell Carcinoma.Molecular cancer research : MCR · 2024Article
- Effects of psoriasis and psoralen exposure on the somatic mutation landscape of the skin.Nature genetics · 2023Article
- Epidermal mutation accumulation in photodamaged skin is associated with skin cancer burden and can be targeted through ablative therapy.Science advances · 2023Article
- Mutation Hotspots Found in Bladder Cancer Aid Prediction of Carcinogenic Risk in Normal Urothelium.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
21 authors at 9 institutions in 3 countries.
Lei WeiDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. lei.wei@roswellpark.org gyorgy.paragh@roswellpark.org.ORCID 0000-0002-1881-8666
Sean R ChristensenDepartment of Dermatology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-2711-0026
Megan E FitzgeraldDepartment of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
James GrahamDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Nicholas D HutsonDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.ORCID 0000-0001-6827-8656
Chi ZhangSchool of Biological Sciences Center for Plant Science and Innovation, University of Nebraska, Lincoln, NE, USA.
Ziyun HuangDepartment of Computer Science and Software Engineering, Penn State Erie, The Behrend College, Erie, PA, USA.
Qiang HuDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.ORCID 0000-0002-4090-5539
Fenglin ZhanDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Jun XieDepartment of Statistics, Purdue University, West Lafayette, IN, USA.
Jianmin ZhangDepartment of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Song LiuDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Eva RemenyikDepartment of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Emese GellenDepartment of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.ORCID 0000-0003-4726-4081
Oscar R ColegioDepartment of Dermatology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Michael BaxDepartment of Dermatology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Jinhui XuDepartment of Computer Science and Engineering, State University of New York at Buffalo, Buffalo, NY, USA.
Haifan LinYale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.
Wendy J HussDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.ORCID 0000-0002-0812-8696
Barbara A FosterDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.ORCID 0000-0003-0459-7011
Gyorgy ParaghDepartment of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. lei.wei@roswellpark.org gyorgy.paragh@roswellpark.org.ORCID 0000-0002-6612-9267
Roswell Park Comprehensive Cancer Center · USUniversity of Debrecen · HULake Erie College of Osteopathic Medicine · USPurdue University West Lafayette · USUniversity at Buffalo, State University of New York · USUniversity of Nebraska–Lincoln · USUniversity of Science and Technology of China · CNYale Cancer Center · USYale University · US
Funding
Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MImmuno-Oncology Translation Network: Data Management and Resource-Sharing Center at RPCIU24CA232979 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI HUTSON, ALAN DAVID, LIU, SONG · 2018 to 2024
$8.9MPromoting Institutional Communities for Open Data ScienceU24ES026465 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2015 to 2017
$7.6MThe role of TAZ in breast cancer initiation and progressionR01CA207504 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI ZHANG, JIANMIN · 2017 to 2021
$2.0MNCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA016056NCI NIH HHS R01 CA207504NCI NIH HHS U24 CA232979NIEHS NIH HHS U24 ES026465
Abstract
In ultraviolet (UV) radiation-exposed skin, mutations fuel clonal cell growth. The relationship between UV exposure and the accumulation of clonal mutations (CMs) and the correlation between CMs and skin cancer risk are largely unexplored. We characterized 450 individual-matched sun-exposed (SE) and non-SE (NE) normal human skin samples. The number and relative contribution of CMs were significantly different between SE and NE areas. Furthermore, we identified hotspots in
Indexed as
Carcinoma, Squamous CellSkin NeoplasmsHumansMutationSkinUltraviolet Rays
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