ArticleScience advances2021
Soft implantable drug delivery device integrated wirelessly with wearable devices to treat fatal seizures.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 199 citations in OpenAlex.
- Soft Ionic and Electronic Triboelectric Nanogenerators: Toward Attachable and Implantable Biomedical Applications.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Fully Wireless and Flexible Valves for Multiplexed and Prolonged Intravesical Liquid Release.Advanced healthcare materials · 2026Article
- Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Nanofluidic-based electrochemical pump for remotely controlled, on-demand drug delivery.Lab on a chip · 2026Article
- Review
- Wearable bioelectronics for skin cancer management.Biomaterials · 2026Review
- Electricity-Based Locoregional Cancer Therapies and Their Associated Drug Delivery Technologies: From Principles of Action to Clinical Implications.Biomaterials research · 2026Review
- Soft bioelectronics for wireless drug delivery: programmable, minimally invasive and closed-loop therapeutics.npj soft matter · 2026Review
- Theoretical Study of Ultra-Fast Laser Lift-Off of Carbon Nanotube-Integrated Polyimide Films.Nanomaterials (Basel, Switzerland) · 2025Article
- Multifunctional Biomedical Devices with Closed-Loop Systems for Precision Therapy.Advanced healthcare materials · 2025Review
- NFC/RFID-enabled wearables and implants for biomedical applications.Microsystems & nanoengineering · 2025Review
- Smart closed-loop drug delivery systems.Nature reviews bioengineering · 2025Article
- A Wireless Implantable Closed-Loop Electrochemical Drug Delivery System.IEEE transactions on biomedical circuits and systems · 2025Article
- Dual-phoretic wireless device for directionally oriented and carrier-free targeted drug delivery.Science advances · 2025Article
- Precision-controlled sequential drug release via electrochemical corrosion of liquid metal nanoparticles.Science advances · 2025Article
- Preparation and Application of Hydrophobic and Breathable Carbon Nanocoils/Thermoplastic Polyurethane Flexible Strain Sensors.Nanomaterials (Basel, Switzerland) · 2025Article
- Vialess heterogeneous skin patch for multimodal monitoring and stimulation.Nature communications · 2025Article
- Arrangement Free Wireless Power Transfer via Strongly Coupled Electrical Resonances.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Multifunctional hydrogel electronics for closed-loop antiepileptic treatment.Science advances · 2024Article
- A bio-feedback-mimicking electrode combining real-time monitoring and drug delivery.Innovation (Cambridge (Mass.)) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Personalized biomedical devices have enormous potential to solve clinical challenges in urgent medical situations. Despite this potential, a device for in situ treatment of fatal seizures using pharmaceutical methods has not been developed yet. Here, we present a novel treatment system for neurological medical emergencies, such as status epilepticus, a fatal epileptic condition that requires immediate treatment, using a soft implantable drug delivery device (SID). The SID is integrated wirelessly with wearable devices for monitoring electroencephalography signals and triggering subcutaneous drug release through wireless voltage induction. Because of the wireless integration, bulky rigid components such as sensors, batteries, and electronic circuits can be moved from the SID to wearables, and thus, the mechanical softness and miniaturization of the SID are achieved. The efficacy of the prompt treatment could be demonstrated with animal experiments in vivo, in which brain damages were reduced and survival rates were increased.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.