ArticleAmerican journal of respiratory and critical care medicine2021
NEDD9 Is a Novel and Modifiable Mediator of Platelet-Endothelial Adhesion in the Pulmonary Circulation.
Open access · greenAbstract read
In one paragraph
Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Understanding the Impact of Hypoxia on Pulmonary Artery Endothelial Cells in Chronic Thromboembolic Pulmonary Hypertension Patients.International journal of molecular sciences · 2026Article
- Current Insights into Clinical, Molecular, and Therapeutic Approaches to Acute Respiratory Distress Syndrome.Medical sciences (Basel, Switzerland) · 2026Review
- Class III Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 in Cardiovascular Health and Disease.Journal of cardiovascular translational research · 2025Review
- Overexpression of Neural Precursor Cell Expressed Developmentally Downregulated 9 (NEDD9) reduces ox-LDL-induced Anoikis in atherosclerotic vascular endothelial cells.International journal of cardiology. Heart & vasculature · 2025Article
- Prediction of pulmonary embolism by an explainable machine learning approach in the real world.Scientific reports · 2025Article
- Convergent evolution in high-altitude and marine mammals: Molecular adaptations to pulmonary fibrosis and hypoxia.Zoological research · 2024Article
- Pulmonary Hypertension: Pharmacological and Non-Pharmacological Therapies.Life (Basel, Switzerland) · 2024Review
- Circulating Biomarkers of Endothelial Dysfunction Associated With Ventilatory Ratio and Mortality in ARDS Resulting From SARS-CoV-2 Infection Treated With Antiinflammatory Therapies.CHEST critical care · 2024Article
- Plasma NEDD9 is increased following SARS-CoV-2 infection and associates with indices of pulmonary vascular dysfunction.Pulmonary circulation · 2024Article
- Pulmonary Hypertension: A Contemporary Review.American journal of respiratory and critical care medicine · 2023Review
- Article
- Inflammation and immunity in the pathogenesis of hypoxic pulmonary hypertension.Frontiers in immunology · 2023Review
- Human umbilical cord mesenchymal stem cell-derived treatment of severe pulmonary arterial hypertension.Nature cardiovascular research · 2022Article
- Harnessing Big Data to Advance Treatment and Understanding of Pulmonary Hypertension.Circulation research · 2022Review
- Pulmonary endothelial NEDD9 and the prothrombotic pathophenotype of acute respiratory distress syndrome due to SARS-CoV-2 infection.Pulmonary circulation · 2022Article
- NEDD9 provides mechanistic insight into the coagulopathy of COVID-19.Pulmonary circulation · 2022Article
- NEDD9, a Hypoxia-upregulated Mediator for Pathogenic Platelet-Endothelial Cell Interaction in Pulmonary Hypertension.American journal of respiratory and critical care medicine · 2021Article
- Transcriptome Analysis Reveals Differential Gene Expression between the Closing Ductus Arteriosus and the Patent Ductus Arteriosus in Humans.Journal of cardiovascular development and disease · 2021Article
Corrections and comments
- Commented on by
Authors and funding
24 authors at 9 institutions in 2 countries.
George A AlbaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, and.
Andriy O SamokhinDepartment of Pathology, Massachusetts General Hospital, Boston, Massachusetts.
Rui-Sheng WangDepartment of Pathology, Massachusetts General Hospital, Boston, Massachusetts.
Ying-Yi ZhangDepartment of Pathology, Massachusetts General Hospital, Boston, Massachusetts.
Bradley M WertheimDivision of Cardiovascular Medicine.
Elena AronsDepartment of Pathology, Massachusetts General Hospital, Boston, Massachusetts.
Edward A GreenfieldDivision of Pulmonary and Critical Care Medicine.
Martina H Lundberg SlingsbyDivision of Hematology and Oncology, Department of Medicine, and.
Julia R CeglowskiDivision of Hematology and Oncology, Department of Medicine, and.
Kathleen J HaleyDivision of Cardiovascular Medicine.
Frederick P BowmanDepartment of Pathology, Massachusetts General Hospital, Boston, Massachusetts.
Yen-Rei YuDepartment of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
John C HaneyDana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
George EngDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Richard N MitchellDivision of Cardiovascular and Thoracic Surgery, Department of Surgery, and.
Anthony SheetsDivision of Cardiovascular and Thoracic Surgery, Department of Surgery, and.
Sara O VargasDivision of Cardiology, Department of Medicine, Duke University Medical Center, Duke University, Durham, North Carolina.
Sachiko SeoDepartment of Pathology, Boston Children's Hospital, Boston, Massachusetts.
Richard N ChannickDepartment of Hematology and Oncology, Dokkyo Medical University, Tochigi, Japan.
Peter J LearyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Ronald Reagan UCLA Medical Center, University of California, Los Angeles, Los Angeles, California; and.ORCID 0000-0001-5716-248X
Sudarshan RajagopalDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, Washington.
Joseph LoscalzoDepartment of Pathology, Massachusetts General Hospital, Boston, Massachusetts.
Elisabeth M BattinelliDivision of Hematology and Oncology, Department of Medicine, and.
Bradley A MaronDepartment of Pathology, Massachusetts General Hospital, Boston, Massachusetts.
Massachusetts General Hospital · USPulmonary and Critical Care Associates · USBoston Children's Hospital · USBrigham and Women's Hospital · USDokkyo Medical University · JPDuke University · USHarvard University · USUniversity of California, Los Angeles · USUniversity of Washington · US
Funding
Boston Biomedical Innovation CenterU54HL119145 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLAN, DAVID E., LOSCALZO, JOSEPH · 2013 to 2021
$18.8MRESPIRATORY RESEARCHT32HL007633 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI George R Washko · 1985 to 2026
$14.9MTRANSLATIONAL PHARMACOLOGY COREP50GM107618 · NIGMS · HARVARD MEDICAL SCHOOL · PI SORGER, PETER KARL · 2014 to 2018
$10.8MMOLECULAR IMMUNOLOGY AND TUMOR BIOLOGYT32CA009216 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI David Michael Langenau · 1985 to 2026
$10.6MCenter for Integrated Approaches to Undiagnosed DiseasesU01HG007690 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSCALZO, JOSEPH · 2014 to 2022
$10.4MInstitutional Career Development CoreKL2TR002542 · NCATS · HARVARD MEDICAL SCHOOL · PI BREDELLA, MIRIAM ANTOINETTE, RUTKOVE, SEWARD B. · 2018 to 2022
$8.7MGPx-3 and Peroxide Flux in the Endothelial CellR37HL061795 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSCALZO, JOSEPH · 2007 to 2016
$4.3MTargeting FAK-NEDD9 protein-protein interaction to prevent focal adhesion assembly and vascular proliferation in pulmonary arterial hypertensionR01HL139613 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Sirano Dhe-Paganon, Bradley Maron · 2018 to 2026
$4.1MPredoctoral Training Program in Molecular and Cellular Biology (Supplement: Mentoring in the Research Environment)T32GM136444 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI MICHAEL A MCMURRAY, Rytis Prekeris · 2020 to 2026
$3.7MNEDD9-SMAD3, fibrinolysis, and chronic thromboembolic pulmonary hypertensionR01HL153502 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI MARON, BRADLEY · 2020 to 2023
$1.7MPLATELET DERIVED REACTIVE OXYGEN SPECIES AND PLAQUER01HL061795 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSCALZO, JOSEPH · 1998 to 2006
$1.6MRole of Resident Monocytes in the Pathogenesis of Pulmonary Arterial HypertensionK08HL121185 · NHLBI · DUKE UNIVERSITY · PI YU, YEN-REI ANDREA · 2015 to 2019
$659kNCATS NIH HHS KL2 TR002542NCI NIH HHS T32 CA009216NHGRI NIH HHS U01 HG007690NHLBI NIH HHS K08 HL121185NHLBI NIH HHS R01 HL061795NHLBI NIH HHS R01 HL139613NHLBI NIH HHS R01 HL153502NHLBI NIH HHS R03 HL158640NHLBI NIH HHS R21 HL145420NHLBI NIH HHS R37 HL061795NHLBI NIH HHS R56 HL131787NHLBI NIH HHS T32 HL007633NHLBI NIH HHS U54 HL119145NIGMS NIH HHS P50 GM107618NIGMS NIH HHS T32 GM136444
Abstract
PubMed holds no abstract for this paper.
Indexed as
Adaptor Proteins, Signal TransducingAnimalsBlood PlateletsCell AdhesionCells, CulturedEndothelial CellsFemaleHumansHypoxiaMaleMiceMiddle AgedModels, AnimalPulmonary CirculationPulmonary EmbolismSignal TransductionAdaptor Proteins, Signal Transducinghypoxiaplateletsthrombosis
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.