ArticleJournal of pineal research2021
Robust stability of melatonin circadian phase, sleep metrics, and chronotype across months in young adults living in real-world settings.
Article in Journal of pineal research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Evening types as determined by subjective and objective measures are more emotional eaters.Obesity (Silver Spring, Md.) · 2023Pooled it
- Prolonged Use of an Automated Insulin Delivery System Improves Sleep in Long-Standing Type 1 Diabetes Complicated by Impaired Awareness of Hypoglycemia.Journal of diabetes science and technology · 2024Trial
- Melatonin Circadian Phase Timing and Stability: Associations With Mood Symptoms Among a Clinically-Enriched Sample of Young Adults With Mood Disorders.Journal of pineal research · 2026Article
- Role of chronotype in depression.World journal of psychiatry · 2025Review
- Preliminary evaluation of dim light melatonin onset as an indicator of nighttime eating in adolescents.Eating behaviors · 2025Article
- Afternoon to early evening bright light exposure reduces later melatonin production in adolescents.Npj biological timing and sleep · 2025Article
- Article
- The real-world association between digital markers of circadian disruption and mental health risks.NPJ digital medicine · 2024Article
- Short-term and long-term phenotypic stability of actigraphic sleep metrics involving repeated sleep loss and recovery.Journal of sleep research · 2024Article
- Adaptation of sleep to daylight saving time is slower in people consuming a high-fat diet.iScience · 2024Article
- Distribution of dim light melatonin offset (DLMOff) and phase relationship to waketime in healthy adults and associations with chronotype.Sleep health · 2024Article
- Pressure Building Against the Clock: The Impact of Circadian Misalignment on Blood Pressure.Current hypertension reports · 2024Review
- Chronotype and Cardiometabolic Parameters in Patients with Bipolar Disorder: Preliminary Findings.Journal of clinical medicine · 2023Article
- Article
- Despite shutdown hardships, remote learning may support some healthier student sleep behaviors.Sleep · 2023Article
- Evaluation of environmental, social, and behavioral modulations of the circadian phase of dancers trained in shifts.iScience · 2022Article
- Melatonin Alleviates Hyperglycemia-Induced Cardiomyocyte Apoptosis via Regulation of Long Non-Coding RNA H19/miR-29c/MAPK Axis in Diabetic Cardiomyopathy.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Chronotype, circadian rhythm, and psychiatric disorders: Recent evidence and potential mechanisms.Frontiers in neuroscience · 2022Review
- A classification approach to estimating human circadian phase under circadian alignment from actigraphy and photometry data.Journal of pineal research · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Appropriate synchronization of the timing of behaviors with the circadian clock and adequate sleep are both important for almost every physiological process. The timing of the circadian clock relative to social (ie, local) clock time and the timing of sleep can vary greatly among individuals. Whether the timing of these processes is stable within an individual is not well-understood. We examined the stability of circadian-controlled melatonin timing, sleep timing, and their interaction across ~ 100 days in 15 students at a single university. At three time points ~ 35-days apart, circadian timing was determined from the dim-light melatonin onset (DLMO). Sleep behaviors (timing and duration) and chronotype (ie, mid-sleep time on free days corrected for sleep loss on school/work days) were determined via actigraphy and analyzed in ~ 1-month bins. Melatonin timing was stable, with an almost perfect relationship strength as determined via intraclass correlation coefficients ([ICC]=0.85); average DLMO timing across all participants only changed from the first month by 21 minutes in month 2 and 5 minutes in month 3. Sleep behaviors also demonstrated high stability, with ICC relationship strengths ranging from substantial to almost perfect (ICCs = 0.65-0.85). Average DLMO was significantly associated with average chronotype (r
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.