Evidence map›Paper›PMID 33523479›Full record

ArticleMedical physics2021

Development and preclinical evaluation of a patient-specific high energy x-ray phase sensitive breast tomosynthesis system.

Muhammad U Ghani, Xizeng Wu, Laurie L Fajardo, Zhengxue Jing, Molly D Wong, Bin Zheng, Farid Omoumi, Yuhua Li, Aimin Yan, Peter Jenkins and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Muhammad U GhaniAdvanced Medical Imaging Center and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK, 73019, USA.
Xizeng WuDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, 35249, USA.
Laurie L FajardoDepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, 84132, USA.
Zhengxue JingHologic, Inc., Newark, DE, 19702, USA.
Molly D WongAdvanced Medical Imaging Center and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK, 73019, USA.
Bin ZhengAdvanced Medical Imaging Center and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK, 73019, USA.
Farid OmoumiAdvanced Medical Imaging Center and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK, 73019, USA.
Yuhua LiAdvanced Medical Imaging Center and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK, 73019, USA.
Aimin YanDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, 35249, USA.
Peter JenkinsDepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, 84132, USA.
Stephen L HillisDepartment of Radiology and Biostatistics, University of Iowa, Iowa City, IA, 52242, USA.
Laura LinstrothDepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, 84132, USA.
Hong LiuAdvanced Medical Imaging Center and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK, 73019, USA.

Funding

Clinical Translation of High Energy Phase-Sensitive X-ray Breast TomosynthesisR01CA193378 · NCI · UNIVERSITY OF OKLAHOMA · PI FAJARDO, LAURIE L, JING, ZHENXUE · 2015 to 2019
$3.0M
A Novel Low Dose and Accurate Phase Sensitive Breast Tomosynthesis (PBT) System based on Photon Counting Detector Technology for Cancer ImagingF32CA250300 · NCI · UNIVERSITY OF OKLAHOMA · PI GHANI, MUHAMMAD U · 2020 to 2021
$116k
NCI NIH HHS F32 CA250300NCI NIH HHS R01 CA193378NIH HHS F32 CA250300NIH HHS R01CA193378Oklahoma Tobacco Settlement Endowment Trust
6 · The paper itself

Abstract

backgroundThis article reports the first x-ray phase sensitive breast tomosynthesis (PBT) system that is aimed for direct translation to clinical practice for the diagnosis of breast cancer. PURPOSE: To report the preclinical evaluation and comparison of the newly built PBT system with a conventional digital breast tomosynthesis (DBT) system. METHODS AND MATERIALS: The PBT system is developed based on a comprehensive inline phase contrast theoretical model. The system consists of a polyenergetic microfocus x-ray source and a flat panel detector mounted on an arm that is attached to a rotating gantry. It acquires nine projections over a 15° angular span in a stop-and-shoot manner. A dedicated phase retrieval algorithm is integrated with a filtered back-projection method that reconstructs tomographic slices. The American College of Radiology (ACR) accreditation phantom, a contrast detail (CD) phantom and mastectomy tissue samples were imaged at the same glandular dose levels by both the PBT and a standard of care DBT system for image quality characterizations and comparisons.

resultsThe PBT imaging scores with the ACR phantom are in good to excellent range and meet the quality assurance criteria set by the Mammography Quality Standard Act. The CD phantom image comparison and associated statistical analyses from two-alternative forced-choice reader studies confirm the improvement offered by the PBT system in terms of contrast resolution, spatial resolution, and conspicuity. The artifact spread function (ASF) analyses revealed a sizable lateral spread of metal artifacts in PBT slices as compared to DBT slices. Signal-to-noise ratio values for various inserts of the ACR and CD phantoms further validated the superiority of the PBT system. Mastectomy sample images acquired by the PBT system showed a superior depiction of microcalcifications vs the DBT system.

conclusionThe PBT imaging technology can be clinically employed for improving the accuracy of breast cancer screening and diagnosis.

Indexed as

Breast NeoplasmsBreastHumansMammographyMastectomyPhantoms, ImagingRadiographic Image EnhancementX-RaysACR phantommastectomy specimenphase contrastphase retrievaltomosynthesis

Identifiers

PMID33523479
PMCPMC8573724

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.