ArticleAdvances in experimental medicine and biology2021
Metabolic Choice Tunes Foxp3+ Regulatory T Cell Function.
Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Early Growth Response Gene 1 Benefits Autoimmune Disease by Promoting Regulatory T Cell Differentiation as a Regulator of Foxp3.Research (Washington, D.C.) · 2025Article
- Engineered T cells and their therapeutic applications in autoimmune diseases.Zoological research · 2022Review
- Comprehensive Analysis ofFrontiers in oncology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic programs and dynamic nutrient signaling can direct cell biological function. Cellular metabolism and biological function are coordinated to cell activity. Regulatory T cells (Foxp3+ Tregs) expressing the key transcription factor FOXP3 play critical roles in the maintenance of immune tolerance and in the control of immune homeostasis. A bundle of data demonstrated that Foxp3+ Tregs were influenced and regulated by Toll-cell receptor (TCR) and costimulatory signals, cytokine conditions and metabolic changes, including metabolites, etc. In this context, Foxp3+ Tregs are impacted by different environmental conditions and metabolic differences associated with diverse transcriptional patterns, which, in turn, display a high degree of plasticity and tissue specificity. During the past decades, significant progresses have been made in understanding the correlation between metabolic changes and manipulation of Foxp3+ Treg function. Taken together, this chapter aims to summarize the important advances in the fields, decipher what metabolic ways are involved in Foxp3+ Tregs, and how metabolism modulates Foxp3 expression, stability, and suppressive functions, which may provide a potential pace on lightening up Foxp3+ Treg-mediated immune functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.