Evidence map›Paper›PMID 33523352›Full record

Observational studyJournal of clinical monitoring and computing2022

Mechanisms contributing to hypotension after anesthetic induction with sufentanil, propofol, and rocuronium: a prospective observational study.

Bernd Saugel, Elisa-Johanna Bebert, Luisa Briesenick, Phillip Hoppe, Gillis Greiwe, Dongsheng Yang, Chao Ma, Edward J Mascha, Daniel I Sessler, Dorothea E Rogge

Registry-linked trialOpen access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of clinical monitoring and computing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06421181 (Hemodynamic Effects of Anesthesia Induction), which is not on this map. Cited by 72 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 5 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06421181 recruitingnot on this mapstarted 2025, after this paper: background citation

Hemodynamic Effects of Anesthesia Induction

TypeobservationalSponsorKliniken Essen-MitteRan2025 to 2026Enrolled30ConditionsPatients Undergoing Anaesthesia Induction
3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 5 syntheses or guidelines pooled it, 116 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Bernd SaugelDepartment of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany. bernd.saugel@gmx.de.ORCID 0000-0001-6619-0722
Elisa-Johanna BebertDepartment of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.
Luisa BriesenickDepartment of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.
Phillip HoppeDepartment of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.
Gillis GreiweDepartment of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.
Dongsheng YangDepartments of Quantitative Health Sciences and Outcomes Research, Lerner Research Institute and Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA.
Chao MaDepartments of Quantitative Health Sciences and Outcomes Research, Lerner Research Institute and Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA.
Edward J MaschaDepartments of Quantitative Health Sciences and Outcomes Research, Lerner Research Institute and Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA.
Daniel I SesslerDepartment of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, USA.
Dorothea E RoggeDepartment of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.
Universität Hamburg · DECleveland Clinic Lerner College of Medicine · USCleveland Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It remains unclear whether reduced myocardial contractility, venous dilation with decreased venous return, or arterial dilation with reduced systemic vascular resistance contribute most to hypotension after induction of general anesthesia. We sought to assess the relative contribution of various hemodynamic mechanisms to hypotension after induction of general anesthesia with sufentanil, propofol, and rocuronium. In this prospective observational study, we continuously recorded hemodynamic variables during anesthetic induction using a finger-cuff method in 92 non-cardiac surgery patients. After sufentanil administration, there was no clinically important change in arterial pressure, but heart rate increased from baseline by 11 (99.89% confidence interval: 7 to 16) bpm (P < 0.001). After administration of propofol, mean arterial pressure decreased by 23 (17 to 28) mmHg and systemic vascular resistance index decreased by 565 (419 to 712) dyn*s*cm

Indexed as

AnestheticsHypotensionPropofolAnesthetics, IntravenousBlood PressureHemodynamicsHumansRocuroniumSufentanilAnestheticsAnesthetics, IntravenousPropofolRocuroniumSufentanilBlood pressureCardiac outputCardiovascular dynamicsHemodynamic monitoringIntraoperative hypotension

Identifiers

PMID33523352
PMCPMC9122881
OpenAlexW3128179576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.