ArticleBehavior genetics2021
Incorporating Polygenic Risk Scores in the ACE Twin Model to Estimate A-C Covariance.
Article in Behavior genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Article
- The Power to Resolve Cultural Transmission and Sibling Interaction Using Polygenic Scores.Behavior genetics · 2026Article
- Article
- Measuring the Associations Between Brain Morphometry and Polygenic Risk Scores for Substance use Disorders in Drug-Naive Adolescents.Behavior genetics · 2025Article
- On the Detection of Population Heterogeneity in Causation Between Two Variables: Finite Mixture Modeling of Data Collected from Twin Pairs.Behavior genetics · 2025Article
- Employing Informatics Strategies in Alzheimer's Disease Research: A Review from Genetics, Multiomics, and Biomarkers to Clinical Outcomes.Annual review of biomedical data science · 2024Review
- On the detection of population heterogeneity in causation between two variables: Finite mixture modeling of data collected from twin pairs.Research square · 2024Article
- Maximizing the value of twin studies in health and behaviour.Nature human behaviour · 2023Review
- Heritability Estimation of Cognitive Phenotypes in the ABCD StudyBehavior genetics · 2023Article
- Annual Research Review: Towards a deeper understanding of nature and nurture: combining family-based quasi-experimental methods with genomic data.Journal of child psychology and psychiatry, and allied disciplines · 2023Review
- Genetic and Environmental Variation in Continuous Phenotypes in the ABCD Study®.Behavior genetics · 2023Article
- Measuring heritable contributions to Alzheimer's disease: polygenic risk score analysis with twins.Brain communications · 2022Article
- Environment-by-PGS Interaction in the Classical Twin Design: An Application to Childhood Anxiety and Negative Affect.Multivariate behavioral researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The assumption in the twin model that genotypic and environmental variables are uncorrelated is primarily made to ensure parameter identification, not because researchers necessarily think that these variables are uncorrelated. Although the biasing effects of such correlations are well understood, a method to estimate these parameters in the twin model would be useful. Here we explore the possibility of relaxing this assumption by adding polygenic scores to the (univariate) twin model. We demonstrate that this extension renders the additive genetic (A)-common environmental (C) covariance (σ
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.