Evidence map›Paper›PMID 33523326›Full record

ArticleBasic research in cardiology2021

Mitigated viral myocarditis in A/J mice by the immunoproteasome inhibitor ONX 0914 depends on inhibition of systemic inflammatory responses in CoxsackievirusB3 infection.

Carl Christoph Goetzke, Nadine Althof, Hannah Louise Neumaier, Arndt Heuser, Ziya Kaya, Meike Kespohl, Karin Klingel, Antje Beling

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Basic research in cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Role of Proteasomes in Inflammation.Journal of clinical medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Carl Christoph GoetzkeDepartment of Pediatrics, Division of Pulmonology, Immunology and Critical Care Medicine, Charité-Universitätsmedizin, Berlin Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.
Nadine AlthofGerman Federal Institute for Risk Assessment, Berlin, Germany.
Hannah Louise NeumaierCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Biochemistry, Charitéplatz 1, 10117, Berlin, Germany.
Arndt HeuserAnimal Phenotyping Platform, Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany.
Ziya KayaUniversitätsklinikum Heidelberg, Medizinische Klinik für Innere Medizin III: Kardiologie, Angiologie und Pneumologie, Heidelberg, Germany.
Meike KespohlCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Biochemistry, Charitéplatz 1, 10117, Berlin, Germany.
Karin KlingelCardiopathology, Institute for Pathology and Neuropathology, University Hospital Tuebingen, Tuebingen, Germany.
Antje BelingCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Biochemistry, Charitéplatz 1, 10117, Berlin, Germany. antje.beling@charite.de.ORCID http://orcid.org/0000-0002-1826-5248
Humboldt-Universität zu Berlin · DEFederal Institute for Risk Assessment · DEHeidelberg University · DELeibniz Association · DEMax Delbrück Center · DE

Funding

Berlin Institute of health MD scholarshipBerlin Institute of Health MD scholarshipCharité - Universitätsmedizin Berlin BIH-Charité Junior Clinician Scientist ProgramDeutsche Forschungsgemeinschaft BE 6335/4Deutsche Forschungsgemeinschaft SFB1292 - TP02Deutsche Forschungsgemeinschaft VO 1602/4Deutsches Zentrum für Herz-Kreislaufforschung (DE) Release from teaching grantStiftung für Experimentelle Biomedizin Hofschneider-Endowed Professorship
6 · The paper itself

Abstract

A preclinical model of troponin I-induced myocarditis (AM) revealed a prominent role of the immunoproteasome (ip), the main immune cell-resident proteasome isoform, in heart-directed autoimmunity. Viral infection of the heart is a known trigger of cardiac autoimmunity, with the ip enhancing systemic inflammatory responses after infection with a cardiotropic coxsackievirusB3 (CV). Here, we used ip-deficient A/J-LMP7

Indexed as

AnimalsAnti-Inflammatory AgentsCells, CulturedCoxsackievirus InfectionsDisease Models, AnimalEnterovirus B, HumanHost-Pathogen InteractionsInflammationMaleMiceMice, KnockoutMyeloid CellsMyocarditisMyocytes, CardiacOligopeptidesProteasome Endopeptidase ComplexAnti-Inflammatory AgentsLMP7 proteinOligopeptidesPR-957Proteasome Endopeptidase ComplexProteasome InhibitorsCytokineInfectionInflammationMyocarditisProteasome

Identifiers

PMID33523326
PMCPMC7851025
OpenAlexW3128423215

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.