Evidence map›Paper›PMID 33523325›Full record

SynthesisProgress in orthodontics2021

The effect of the local administration of biological substances on the rate of orthodontic tooth movement: a systematic review of human studies.

Sarah Abu Arqub, Vaibhav Gandhi, Marissa G Iverson, Maram Ahmed, Chia-Ling Kuo, Jinjian Mu, Eliane Dutra, Flavio Uribe

2 registry-linked trialsOpen access · diamondAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Progress in orthodontics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05766618 phase3unknown statusnot on this mapstarted 2023, after this paper: background citation

The Effect of Multiple Injections of Platelets Rich Fibrin (i-PRF) on The Rate of Canine Retraction A Split-mouth: A Randomized Controlled Trial

TypeinterventionalSponsorCairo UniversityRan2023 to 2024Enrolled22ConditionsPlatelet-Rich Fibrin, Acceleration, OrthodonticsArmsInjectable platelet rich fibrin (i-PRF): in acceleration of orthodontic tooth movement
NCT07479290 phase1recruitingnot on this mapstarted 2026, after this paper: background citation

Effect Of Local Use Of 1,25 Dihydroxycholecalciferol on Rate of Canine Distillization: A Split Mouth Randomized Control Trial

TypeinterventionalSponsorFoundation University IslamabadRan2026 to 2027Enrolled30ConditionsMalocclusion of Anterior TeethArmsExperimental: 1,25 DHC injection, Placebo: plain DMSO solvent
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
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  6. Observational
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  8. Review
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  13. Potential Uses ofJournal of pharmacy & bioallied sciences · 2023
    Review
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  15. Review
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  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sarah Abu ArqubDivision of Orthodontics, University of Connecticut Health, 263 Farmington Ave, Farmington, CT, 06032, USA.
Vaibhav GandhiDivision of Orthodontics, University of Connecticut Health, 263 Farmington Ave, Farmington, CT, 06032, USA.
Marissa G IversonL.M. Stowe Library, University of Connecticut Health, Farmington, CT, USA.
Maram AhmedDivision of Orthodontics, University of Boston, Boston, MA, USA.
Chia-Ling KuoConnecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health, Farmington, CT, USA.
Jinjian MuConnecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health, Farmington, CT, USA.
Eliane DutraDivision of Orthodontics, University of Connecticut Health, 263 Farmington Ave, Farmington, CT, 06032, USA. edutra@uchc.edu.ORCID http://orcid.org/0000-0003-4592-0954
Flavio UribeDivision of Orthodontics, University of Connecticut Health, 263 Farmington Ave, Farmington, CT, 06032, USA.
UConn Health · USBoston University · US

Funding

The role of FGFR3 in the effects of PTH in the Mandibular CondyleK01DE029528 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI DUTRA, ELIANE · 2020 to 2024
$934k
NIDCR NIH HHS K01 DE029528
6 · The paper itself

Abstract

backgroundThe influence of different biological agents on the rate of orthodontic tooth movement (OTM) has been extensively reviewed in animal studies with conflicting results. These findings cannot be extrapolated from animals to humans. Therefore, we aimed to systematically investigate the most up-to-date available evidence of human studies regarding the effect of the administration of different biological substances on the rate of orthodontic tooth movement.

methodsA total of 8 databases were searched until the 16th of June 2020 without restrictions. Controlled randomized and non-randomized human clinical studies assessing the effect of biological substances on the rate of OTM were included. ROBINS-I and the Cochrane Risk of Bias tools were used. Reporting of this review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

resultsA total of 11 studies (6 randomized clinical trials and 5 prospective clinical trials) were identified for inclusion. Local injections of prostaglandin E1 and vitamin C exerted a positive influence on the rate of OTM; vitamin D showed variable effects. The use of platelet-rich plasma and its derivatives showed inconsistent results, while the local use of human relaxin hormone showed no significant effects on the rate of OTM. LIMITATIONS: The limited and variable observation periods after the administration of the biological substances, the high and medium risk of bias assessment for some included studies, the variable concentrations of the assessed biological agents, the different experimental designs and teeth evaluated, and the variety of measurement tools have hampered the quantitative assessment of the results as originally planned. CONCLUSIONS AND IMPLICATIONS: Despite the methodological limitations of the included studies, this systematic review provides an important overview of the effects of a variety of biological agents on the rate of tooth movement and elucidates the deficiencies in the clinical studies that have been conducted so far to evaluate the effectiveness of these agents in humans, providing some guidelines for future robust research.

trial registrationPROSPERO ( CRD42020168481 , www.crd.york.ac.uk/prospero ).

Indexed as

ToothTooth Movement TechniquesAnimalsBiological FactorsHumansProspective StudiesResearch DesignBiological FactorsAccelerationBiological agentsHuman trialsOrthodontic tooth movementPlatelet-rich plasmaProstaglandinsRelaxinVitamin CVitamin D

Identifiers

PMID33523325
PMCPMC7851211
OpenAlexW3126403181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.