Evidence map›Paper›PMID 33523298›Full record

ReviewPediatric nephrology (Berlin, Germany)2021

Emerging monitoring technologies in kidney transplantation.

Abdulla Ehlayel, K'joy J A Simms, Isa F Ashoor

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric nephrology (Berlin, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Abdulla Ehlayel *Children's Hospital New Orleans, 200 Henry Clay Ave, New Orleans, LA, 70118, USA.
K'joy J A Simms *Children's Hospital New Orleans, 200 Henry Clay Ave, New Orleans, LA, 70118, USA.
Isa F AshoorChildren's Hospital New Orleans, 200 Henry Clay Ave, New Orleans, LA, 70118, USA. iashoo@lsuhsc.edu.ORCID 0000-0003-0539-4021
Children's Hospital of New Orleans · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-invasive technologies to monitor kidney allograft health utilizing high-throughput assays of blood and urine specimens are emerging out of the research realm and slowly becoming part of everyday clinical practice. HLA epitope analysis and eplet mismatch score determination promise a more refined approach to the pre-transplant recipient-donor HLA matching that may lead to reduced rejection risk. High-resolution HLA typing and multiplex single antigen bead assays are identifying potential new offending HLA antibody subtypes. There is increasing recognition of the deleterious role non-HLA antibodies play in post-transplant outcomes. Donor-derived cell-free DNA detected by next-generation sequencing is a promising biomarker for kidney transplant rejection. Multi-omics techniques are shedding light on discrete genomic, transcriptomic, proteomic, and metabolomic signatures that correlate with and predict allograft outcomes. Over the next decade, a comprehensive approach to optimize kidney matching and monitor transplant recipients for acute and chronic graft dysfunction will likely involve a combination of those emerging technologies summarized in this review.

Indexed as

Kidney TransplantationGraft RejectionGraft SurvivalHistocompatibility TestingHLA AntigensHumansProteomicsHLA AntigensBiomarkerEmerging technologiesGraft dysfunctionKidney transplantMulti-omicsRejection

Identifiers

PMID33523298
OpenAlexW3126871639

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.