Evidence map›Paper›PMID 33523277›Full record

SynthesisSurgical endoscopy2022

Primary obesity surgery endoluminal (POSE) for the treatment of obesity: a systematic review and meta-analysis.

Shailendra Singh, Ahmad Najdat Bazarbashi, Ahmad Khan, Monica Chowdhry, Mohammad Bilal, Diogo Turiani Hourneaux de Moura, Pichamol Jirapinyo, Shyam Thakkar, Christopher C Thompson

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Surgical endoscopy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05725967 (Endoscopic Metabolic and Bariatric Therapies), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05725967 enrolling by invitationnot on this map

Endoscopic Metabolic and Bariatric Therapies

Typeobservational_patient_registrySponsorChristopher C. Thompson, MD, MScRan2022 to 2029Enrolled5,000ConditionsObesity, Obesity, Morbid, Obesity Associated Disorder, Bariatric Surgery CandidateArmsPrimary Obesity Endoscopic Procedures, Endoscopic Revision of Bariatric Surgical Procedures, Bariatric Surgery Procedures, Endoscopic Sleeve Gastroplasty, Trans-oral Outlet Reduction, Intragastric Balloon
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Acupoint catgut embedding for simple obesity in animal studies: a systematic review and Meta-analysis.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023
    Pooled it
  3. Observational
  4. Article
  5. Article
  6. Endoscopic bariatrics: Current status and emerging technologies.World journal of gastrointestinal endoscopy · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Endoscopic Bariatric Therapy for Obesity and Metabolic Syndrome.The Korean journal of helicobacter and upper gastrointestinal research · 2023
    Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Primary Bariatric Procedures.Digestive diseases and sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shailendra SinghDivision of Gastroenterology and Hepatology, West Virginia University, 5th Floor Suite 5500, Morgantown, WV, 26506, USA. shail121@gmail.com.ORCID 0000-0001-9505-4842
Ahmad Najdat BazarbashiDivision of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ahmad KhanWest Virginia University Health Sciences Center Charleston Division, Charleston, WV, USA.
Monica ChowdhryWest Virginia University Health Sciences Center Charleston Division, Charleston, WV, USA.
Mohammad BilalDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Diogo Turiani Hourneaux de MouraDivision of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Pichamol JirapinyoDivision of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Shyam ThakkarDivision of Gastroenterology and Hepatology, West Virginia University, 5th Floor Suite 5500, Morgantown, WV, 26506, USA.
Christopher C ThompsonDivision of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Sijin Wen · 2012 to 2026
$81.0M
NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

backgroundPrimary obesity surgery endoluminal (POSE) utilizes an incision-less operating platform system to create full-thickness plications in the gastric fundus and body (original POSE). Many studies have demonstrated the safety and efficacy of original POSE for the treatment of obesity.

objectiveWe aimed to conduct a systematic review and meta-analysis of available literature in an attempt to evaluate the outcomes of original POSE per the ASGE task force thresholds.

methodsBibliographic databases were systematically searched for studies assessing the outcomes of POSE for the treatment of obesity. All randomized controlled trials (RCTs) and observational studies that assessed outcomes of POSE were included. Studies were included if they reported percent total weight loss (%TWL) or percent excess weight loss (%EWL) and the incidence of serious adverse events (SAE).

resultsA total of seven studies with 613 patients were included. Two included studies were RCTs, while the remaining were observational studies. Pooled mean %EWL at 3-6 months and 12-15 months were 42.62 (95% CI 37.56-47.68) and 48.86 (95% CI 42.31-55.41), respectively. Pooled mean %TWL at 3-6 months and 12-15 months was 13.45 (95% CI 8.93-17.97) and 12.68 (95% CI 8.13-17.23), respectively. Subgroup analysis of two RCTs showed that weight loss at 1 year was significantly higher in POSE patients (%EWL difference in means 19.45 (95% CI 4.65-34.24, p value = 0.01). The overall incidence of serious adverse events was only 2.84% and included GI bleeding, extra-gastric bleeding, hepatic abscess, severe pain, severe nausea, and severe vomiting. The mean number of total anchors placed in the fundus and body was 13.18 (95% CI 11.77-14.58), and the mean procedure time was 44.55 min (95% CI 36.44-52.65).

conclusionPOSE, a minimally invasive endoscopic bariatric therapy, is a safe and effective modality for the treatment of obesity. The outcomes of POSE meet and surpass the ASGE joint task force thresholds. Future studies should evaluate newer versions of this procedure that emphasize gastric body plication sparing the fundus.

Indexed as

Bariatric SurgeryGastroplastyObesity, MorbidHumansObesityTreatment OutcomeWeight LossEBMTsEndoscopic bariatric and metabolic therapiesEndoscopic bariatric therapyEndoscopic gastroplastyPOSEPrimary obesity surgery endoluminalWeight loss

Identifiers

PMID33523277
PMCPMC8389059

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.