ArticleJournal of the National Cancer Institute2021
Defining Multimorbidity and Its Impact in Older United States Veterans Newly Treated for Multiple Myeloma.
Article in Journal of the National Cancer Institute, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Emergency diagnosis of multiple myeloma: a SEER-Medicare study.Cancer causes & control : CCC · 2026Article
- Using electronic health records to understand multimorbidity in older people: a scoping review.European geriatric medicine · 2025Article
- Psychiatric and substance use disorders predict poor outcomes in older veterans with acute myeloid leukemia.Blood advances · 2025Article
- Multimorbidity and Its Impact in Older U.S. Veterans Newly Treated for Advanced Non-Small Cell Lung Cancer.Annals of the American Thoracic Society · 2025Article
- Patterns of multimorbidity in older adults with multiple myeloma: An analysis of SEER-Medicare.PloS one · 2025Article
- Natural Language Processing Algorithm to Extract Multiple Myeloma Stage From Oncology Notes in the Veterans Affairs Healthcare System.JCO clinical cancer informatics · 2024Article
- Building Research Infrastructure to Develop Greater Learning Efficiencies (BRIDGE).Studies in health technology and informatics · 2024Article
- Natural Language Processing-Assisted Classification Models to Confirm Monoclonal Gammopathy of Undetermined Significance and Progression in Veterans' Electronic Health Records.JCO clinical cancer informatics · 2023Article
- Multimorbidity in patients with monoclonal gammopathy of undetermined significance.International journal of cancer · 2023Article
- Health-related quality of life and use of medication with anticholinergic activity in patients with multiple myeloma.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Validation of algorithms to select patients with multiple myeloma and patients initiating myeloma treatment in the national Veterans Affairs Healthcare System.Pharmacoepidemiology and drug safety · 2023Article
- Risk factors of SARS-CoV-2 infection and complications from COVID-19 in lung cancer patients.International journal of clinical oncology · 2023Article
- Multimorbidity Patterns in US Adults with Subjective Cognitive Decline and Their Relationship with Functional Difficulties.Journal of aging and health · 2022Article
- Article
- Disulfiram use is associated with lower risk of COVID-19: A retrospective cohort study.PloS one · 2021Observational
- Abiraterone or Enzalutamide for Patients With Metastatic Castration-Sensitive Prostate Cancer: A Nationwide Veterans Affairs Study.JCO clinical cancer informaticsArticle
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Authors and funding
15 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundTraditional count-based measures of comorbidity are unlikely to capture the complexity of multiple chronic conditions (multimorbidity) in older adults with cancer. We aimed to define patterns of multimorbidity and their impact in older United States veterans with multiple myeloma (MM).
methodsWe measured 66 chronic conditions in 5076 veterans aged 65 years and older newly treated for MM in the national Veterans Affairs health-care system from 2004 to 2017. Latent class analysis was used to identify patterns of multimorbidity among these conditions. These patterns were then assessed for their association with overall survival, our primary outcome. Secondary outcomes included emergency department visits and hospitalizations.
resultsFive patterns of multimorbidity emerged from the latent class analysis, and survival varied across these patterns (log-rank 2-sided P < .001). Older veterans with cardiovascular and metabolic disease (30.9%, hazard ratio [HR] = 1.33, 95% confidence interval [CI] = 1.21 to 1.45), psychiatric and substance use disorders (9.7%, HR = 1.58, 95% CI = 1.39 to 1.79), chronic lung disease (15.9%, HR = 1.69, 95% CI = 1.53 to 1.87), and multisystem impairment (13.8%, HR = 2.25, 95% CI = 2.03 to 2.50) had higher mortality compared with veterans with minimal comorbidity (29.7%, reference). Associations with mortality were maintained after adjustment for sociodemographic variables, measures of disease risk, and the count-based Charlson Comorbidity Index. Multimorbidity patterns were also associated with emergency department visits and hospitalizations.
conclusionsOur findings demonstrate the need to move beyond count-based measures of comorbidity and consider cancer in the context of multiple chronic conditions.
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