ArticleInteractive cardiovascular and thoracic surgery2021
Women have a higher resection rate for lung cancer and improved survival after surgery.
Article in Interactive cardiovascular and thoracic surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Multifactorial Impact of Age, Race, and Female Sex on Management of Non-small Cell Lung Cancer.Annals of surgical oncology · 2026Article
- Lung cancer resection rate and outcomes during the COVID-19 pandemic in Northern Finland.Acta oncologica (Stockholm, Sweden) · 2025Article
- Perioperative Outcomes of Lung Cancer Surgery in Women: A Canadian Nationwide Retrospective Cohort Study.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Article
- Intersection of Race, Rurality, and Income in Defining Access to Minimally Invasive Lung Surgery.The Annals of thoracic surgery · 2025Article
- The prognostic significance of modified frailty index-5 in patients undergoing pneumonectomy for lung cancer.Interdisciplinary cardiovascular and thoracic surgery · 2024Article
- [Gender medicine in lung diseases].Chirurgie (Heidelberg, Germany) · 2024Review
- Article
- Gender Medicine in Clinical Radiology Practice.Journal of personalized medicine · 2023Review
- Sex-specificity in Surgical Stages of Lung Cancer in Young Adults.The open respiratory medicine journal · 2023Article
- The Effect of Timeliness of Care on Lung Cancer Survival - A Population-Based Approach.Annals of global health · 2023Article
- The evolving landscape of sex-based differences in lung cancer: a distinct disease in women.European respiratory review : an official journal of the European Respiratory Society · 2022Article
- Six MicroRNA Prognostic Models for Overall Survival of Lung Adenocarcinoma.Genetics research · 2022Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesSurgery is the standard treatment in early-stage non-small-cell lung cancer and select cases of small-cell lung cancer, but gender differences in its use and outcome are poorly known. Gender differences in surgical resection rates and long-term survival after lung cancer surgery were therefore investigated.
methodsIn Finland, 3524 patients underwent resection for primary lung cancer during 2004-2014. Surgical rate and mortality data were retrospectively retrieved from 3 nationwide compulsory registries. Survival was studied by comparing propensity-matched cohorts. Median follow-up was 8.6 years.
resultsSurgery rate was higher in women (15.9% vs 12.3% in men, P < 0.0001). Overall survival was 85.3% 1 year, 51.4% 5 years, 33.4% 10 years and 24.2% at 14 years from surgery. In matched groups, survival after resection was better in women after 1 year (91.3% vs 83.3%), 5 years (60.2% vs 48.6%), 10 years (43.7% vs 27.9%) and 14 years (29.0% vs 21.1%) after surgery [hazard ratio (HR) 0.66; confidence interval (CI) 0.58-0.75; P < 0.0001]. Of all first-year survivors, 39.1% were alive 10 years and 28.3% 14 years after surgery. Among these matched first-year survivors, women had higher 14-year survival (36.9% vs 25.3%; HR 0.75; CI 0.65-0.87; P = 0.0002).
conclusionsSurgery is performed for lung cancer more often in women. Women have more favourable short- and long-term outcome after lung cancer surgery. Gender discrepancy in survival continues to increase beyond the first year after surgery.
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