ArticleEmerging topics in life sciences2019
Developments in molecular epidemiology of aging.
Article in Emerging topics in life sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Post-traumatic stress disorder moderates the association between BrainAge acceleration and GrimAge acceleration.Neurobiology of aging · 2026Pooled it
- Associations of breast DNA methylation-based measures of biological ageing with obesity-related breast cancer risk markers.Epigenetics · 2026Article
- Longitudinal associations of cumulative and repeated-measure patterns of insulin resistance surrogate indices with biological age acceleration and incident cardiovascular disease across cardiovascular-kidney-metabolic syndrome stages 0-3: evidence from CHARLS 2011-2020.Cardiovascular diabetology · 2026Article
- Accelerated biological aging is associated with faster multimorbidity progression: a UK biobank study.GeroScience · 2026Article
- Article
- Comprehensive cross-sectional and longitudinal comparison of sixteen markers of biological aging from the Berlin Aging Study II.Communications medicine · 2026Article
- Association of various insulin resistance surrogate indices with aging acceleration and future risk of cardiovascular disease in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: insights from CHARLS 2011-2020 data.Cardiovascular diabetology · 2026Article
- Accelerated biological aging and risk of sarcopenia: evidence from 29,000 Chinese adults.Biology of sport · 2026Article
- The association between dietary iron intake and the incidence of cardiometabolic multimorbidity: the mediating role of biological age.BMC public health · 2025Article
- Association of biological age acceleration with poor outcome after endovascular thrombectomy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Biological aging and incident cardiovascular diseases in individuals with diabetes: insights from a large prospective cohort study.Cardiovascular diabetology · 2025Article
- Sarcopenic obesity, physical activity, and their combined impact on biological aging in US adults.BMC public health · 2025Article
- Associations between environmental air pollution, greenspace and apparent biological aging: a cross-sectional study.GeroScience · 2025Article
- Social Vulnerability and Biological Aging in New York City: An Electronic Health Records-Based Study.Journal of urban health : bulletin of the New York Academy of Medicine · 2025Article
- Assessing thyroid health: phenotypic age compared to chronological age.Frontiers in endocrinology · 2025Article
- Association between accelerated biological aging and colorectal cancer: a cross-sectional study.Frontiers in medicine · 2025Article
- Association between plant and animal protein and biological aging: findings from the UK Biobank.European journal of nutrition · 2024Article
- Association of biological aging with prostate cancer: insights from the National Health and Nutrition Examination Survey.Aging clinical and experimental research · 2024Article
- Associations of daily eating frequency and nighttime fasting duration with biological aging in National Health and Nutrition Examination Survey (NHANES) 2003-2010 and 2015-2018.The international journal of behavioral nutrition and physical activity · 2024Article
- U-shaped association between sleep duration and biological aging: Evidence from the UK Biobank study.Aging cell · 2024Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The field of molecular epidemiology of aging involves the application of molecular methods to measure aging processes and their genetic determinants in human cohorts. Over the last decade, the field has undergone rapid progress with a dramatic increase in the number of papers published. The aim of this review is to give an overview of the research field, with a specific focus on new developments, opportunities, and challenges. Aging occurs at multiple hierarchical levels. There is increasing consensus that aging-related changes at the molecular level cause declines in physiological integrity, functional capacity, and ultimately lifespan. Molecular epidemiology studies seek to quantify this process. Telomere length, composite scores integrating clinical biomarkers, and omics clocks are among the most well-studied metrics in molecular epidemiology studies. New developments in the field include bigger data and hypothesis-free analysis together with new modes of collaborations in interdisciplinary teams and open access norms around data sharing. Key challenges facing the field are the lack of a gold standard by which to evaluate molecular measures of aging, inconsistency in which metrics of aging are measured and analyzed across studies, and a need for more longitudinal data necessary to observe change over time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.